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DIC Score in Pregnant Women – A Population Based Modification of the International Society on Thrombosis and Hemostasis Score
- Source :
- Erez, O; Novack, L; Beer-Weisel, R; Dukler, D; Press, F; Zlotnik, A; et al.(2014). DIC score in pregnant women-A population based modification of the international society on thrombosis and hemostasis score. PLoS ONE, 9(4). doi: 10.1371/journal.pone.0093240. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9z22p2vt, PLoS ONE, Vol 9, Iss 4, p e93240 (2014), PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- ObjectivesThe objectives of this study were: 1) To determine the component needed to generate a validated DIC score during pregnancy. 2) To validate such scoring system in the identification of patients with clinical diagnosis of DIC.Material and methodsThis is a population based retrospective study, including all women who gave birth at the 'Soroka University Medical Center' during the study period, and have had blood coagulation tests including complete blood cell count, prothrombin time (PT)(seconds), partial thromboplastin time (aPTT), fibrinogen, and D-dimers. Nomograms for pregnancy were established, and DIC score was constructed based on ROC curve analyses.Results1) maternal plasma fibrinogen concentrations increased during pregnancy; 2) maternal platelet count decreased gradually during gestation; 3) the PT and PTT values did not change with advancing gestation; 4) PT difference had an area under the curve (AUC) of 0.96 (pConclusionWe could establish a sensitive and specific pregnancy adjusted DIC score. The positive likelihood ratio of this score suggests that a patient with a score of ≥26 has a high probability to have DIC.
- Subjects :
- Critical Care and Emergency Medicine
Maternal Health
Gastroenterology
Likelihood ratios in diagnostic testing
Labor and Delivery
Pregnancy
hemic and lymphatic diseases
Medicine and Health Sciences
Blood coagulation test
Multidisciplinary
medicine.diagnostic_test
Area under the curve
Obstetrics and Gynecology
Hematology
Research Design
Medicine
Gestation
Female
Research Article
circulatory and respiratory physiology
Partial thromboplastin time
medicine.medical_specialty
Clinical Research Design
Science
Critical Care Team Organization
Research and Analysis Methods
Hypertensive Disorders in Pregnancy
Internal medicine
medicine
Humans
Blood Coagulation
Retrospective Studies
Prothrombin time
Hemostasis
Coagulation Disorders
business.industry
Fibrinogen
Thrombosis
Disseminated Intravascular Coagulation
Nomogram
medicine.disease
Surgery
Pregnancy Complications
Birth
Prothrombin Time
Women's Health
business
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....d97dee232c7d1b43db2600371cea42c3