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Control of cell death pathways by HTLV-1 proteins
- Source :
- Frontiers in Bioscience. :3338
- Publication Year :
- 2009
- Publisher :
- IMR Press, 2009.
-
Abstract
- Individuals infected with HTLV-1 harbor the virus mainly in CD4+ memory T-cells as a lifelong infection that remains subclinical in the majority of cases. However, about 3-5% of HTLV-1-infected individuals develop an aggressive T-cell neoplasia (ATLL) or a neurodegenerative disease (TSP/HAM) after a latency period ranging from years to decades. This review summarizes the current knowledge of the effects of the HTLV-1 proteins Tax, p13 and p12 on cell death and survival pathways. Tax, the major oncogenic determinant of HTLV-1, enhances cell survival through its effects on the NF-kappaB, CREB and AKT pathways and on the tumor suppressors p53 and Rb. p13 is targeted to the inner mitochondrial membrane and sensitizes cells to the Fas/ceramide apoptotic pathway and reactive oxygen species-mediated cell death. p12 enhances release of calcium from the endoplasmic reticulum and therefore may influence calcium-dependent apoptotic signals, including opening of the mitochondrial permeability transition pore. The long-term fate of HTLV-1-infected cells (apoptosis, survival, transformation) may therefore depend on the balance of the effects of Tax, p13 and p12 on cell death pathways.
- Subjects :
- Human T-lymphotropic virus 1
Programmed cell death
Ceramide
Cell Death
Cell Survival
Cell growth
viruses
Biology
Mitochondrion
Cell biology
Viral Proteins
chemistry.chemical_compound
Mitochondrial permeability transition pore
chemistry
Apoptosis
hemic and lymphatic diseases
Homeostasis
Humans
Leukemia-Lymphoma, Adult T-Cell
Inner mitochondrial membrane
Protein kinase B
Cell Proliferation
Subjects
Details
- ISSN :
- 10934715 and 10939946
- Database :
- OpenAIRE
- Journal :
- Frontiers in Bioscience
- Accession number :
- edsair.doi.dedup.....d983a6cfe198deba34d75e1ca0b25a79