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Immune Dysfunction and Coinfection with Human Immunodeficiency Virus and Schistosoma japonicum in Yi People
- Source :
- Journal of Immunology Research, Vol 2018 (2018), Journal of Immunology Research
- Publication Year :
- 2018
- Publisher :
- Hindawi Limited, 2018.
-
Abstract
- Objective. To explore the association between infections with HIV and Schistosoma japonicum, and to determine the influences of the HIV-S. japonicum coinfections on the immune system of Yi people. Methods. A block design study was conducted in a Yi county in southwestern China, one of the endemic areas of both HIV/AIDS and S. japonicum in China. All participants were screened for HIV antibodies and S. japonicum antibodies (SjAb) and were classified into four groups: HIV(+)/S. japonicum(−), HIV(−)/S. japonicum (+), HIV(+)/S. japonicum(+), and HIV(−)/S. japonicum(−). Results. There were significant differences among the four groups in both CD4+ T lymphocytes and CD8+ T lymphocytes, but no significant difference in CD3+ T lymphocytes. Both the CD4+ T lymphocyte counts and the ratio of CD4+/CD8+ were lower in HIV-infected people compared with those uninfected. People infected with S. japonicum had increased CD4+ T lymphocyte counts but reduced CD8+ T lymphocyte counts. Similarly, the ratio of CD4+/CD8+ was higher in S. japonicum-infected people compared with those uninfected. People coinfected with HIV and S. japonicum had lower CD4+ T lymphocyte counts, lower ratio of CD4+/CD8+, and higher CD8+ T lymphocyte counts compared with those infected with HIV only or S. japonicum only. People infected with HIV only and those coinfected with HIV and S. japonicum had a higher level of IFN-γ compared with people with no infection. There were no significant differences between people infected with HIV only and with S. japonicum only in the levels of IFN-γ and IL-10. Conclusions. People coinfected with HIV and S. japonicum might have a suppressed immune function because of a decrease in CD4+ T lymphocyte counts, a lowered ratio of CD4+/CD8+, and an increase in CD8+ T lymphocyte counts. Coinfection with HIV and S. japonicum would alter the level of IFN-γ in plasma.
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
Male
lcsh:Immunologic diseases. Allergy
0301 basic medicine
China
Article Subject
Adolescent
CD3
030231 tropical medicine
Immunology
Antibodies, Helminth
HIV Infections
CD8-Positive T-Lymphocytes
Antibodies, Viral
Schistosoma japonicum
Interferon-gamma
Young Adult
03 medical and health sciences
0302 clinical medicine
Immune system
Acquired immunodeficiency syndrome (AIDS)
parasitic diseases
medicine
Animals
Humans
Immunology and Allergy
Lymphocyte Count
biology
Coinfection
HIV
virus diseases
food and beverages
General Medicine
T lymphocyte
Middle Aged
medicine.disease
biology.organism_classification
Virology
030104 developmental biology
Schistosomiasis japonica
biology.protein
Female
Antibody
lcsh:RC581-607
CD8
Research Article
Subjects
Details
- ISSN :
- 23147156 and 23148861
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology Research
- Accession number :
- edsair.doi.dedup.....d992f24a999fce36adc3ee0bbbee7f35