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The role of neoadjuvant imatinib mesylate therapy in sphincter-preserving procedures for anorectal gastrointestinal stromal tumor
- Source :
- American journal of clinical oncology. 34(3)
- Publication Year :
- 2010
-
Abstract
- To explore the role of neoadjuvant imatinib mesylate (IM) therapy in sphincter-preserving procedures for anorectal gastrointestinal stromal tumor (GIST).Between January and December of 2007, 3 patients with primary anorectal GIST who declined recommendations to receive abdominoperineal resection of the rectum, were treated with IM at a single institution. Tumor size, distance to anal edge, and the number of mitoses were compared before and after the treatment. After 12 weeks of IM therapy, conservative surgical procedures were performed.After IM therapy for the 3 patients, computed tomography scan, colonoscopy, and biopsy showed a decrease in size of the rectal mass, an extension in the distance to anal edge, and a reduction in mitotic count. During this treatment regimen, the patients did not experience any side effects. A sphincter-preserving transsacral excision with direct coloanal anastomosis was performed and the resection margins were uninvolved on all sides. During 22 to 28 months postoperatively, the function of anal sphincter was satisfactory and no recurrence occurred among all 3 patients.Neoadjuvant IM therapy for anorectal GIST is safe and effective. Tumor shrinkage and an extension of the distance to anal edge have a clear benefit for the local excision, in terms of feasibility, function preservation, and safety.
- Subjects :
- Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Gastrointestinal Stromal Tumors
medicine.medical_treatment
Anal Canal
Antineoplastic Agents
Piperazines
Internal medicine
Protein-Tyrosine Kinases
medicine
Humans
Stromal tumor
neoplasms
Protein Kinase Inhibitors
Neoadjuvant therapy
Aged
GiST
business.industry
Rectal Neoplasms
Anal canal
Middle Aged
Anus Neoplasms
digestive system diseases
Anus neoplasms
Neoadjuvant Therapy
medicine.anatomical_structure
Imatinib mesylate
Pyrimidines
Treatment Outcome
Benzamides
Imatinib Mesylate
Sphincter
Feasibility Studies
Female
business
Subjects
Details
- ISSN :
- 1537453X
- Volume :
- 34
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- American journal of clinical oncology
- Accession number :
- edsair.doi.dedup.....d997c81233858ac73f9d2e6f9bbe4eda