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An epidemiologic model to project the impact of changes in glomerular filtration rate on quality of life and survival among persons with chronic kidney disease
- Source :
- International Journal of Nephrology and Renovascular Disease
- Publication Year :
- 2014
- Publisher :
- Dove Press, 2014.
-
Abstract
- Adrian R Levy,1,2 Robert M Perkins,3 Karissa M Johnston,2 Sean D Sullivan,4 Vipan C Sood,5 Wendy Agnese,5 Mark A Schnitzler61Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada; 2Oxford Outcomes Ltd, Vancouver, BC, Canada; 3Center for Health Research and Division of Nephrology, Geisinger Health System, Danville, PA, USA; 4School of Pharmacy, University of Washington, Seattle, WA, USA; 5Mitsubishi Tanabe Pharma America, Jersey City, NJ, USA; 6Departments of Internal Medicine and Community Health, Saint Louis University, St Louis, MO, USAPurpose: Predicting the timing and number of end-stage renal disease (ESRD) cases from a population of individuals with pre-ESRD chronic kidney disease (CKD) has not previously been reported. The objective is to predict the timing and number of cases of ESRD occurring over the lifetime of a cohort of hypothetical CKD patients in the US based on a range of baseline estimated glomerular filtration rate (eGFR) values and varying rates of eGFR decline.Methods: A three-state Markov model – functioning kidney, ESRD, and death – with an annual cycle length is used to project changes in baseline eGFR on long-term health outcomes in a hypothetical cohort of CKD patients. Using published eGFR-specific risk equations and adjusting for predictive characteristics, the probability of ESRD (eGFR
- Subjects :
- medicine.medical_specialty
policy analysis
Cost effectiveness
Population
International Journal of Nephrology and Renovascular Disease
Renal function
urologic and male genital diseases
End stage renal disease
disease progression
Internal medicine
Medicine
education
Original Research
education.field_of_study
end-stage renal disease
cost effectiveness
business.industry
Hazard ratio
Acute kidney injury
medicine.disease
female genital diseases and pregnancy complications
acute kidney injury
Nephrology
Cohort
epidemiology
decision model
business
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 11787058
- Database :
- OpenAIRE
- Journal :
- International Journal of Nephrology and Renovascular Disease
- Accession number :
- edsair.doi.dedup.....d99c0a55288a579506f0a951ab9b8005