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Footprints of microRNAs in Cancer Biology
- Source :
- Biomedicines, Biomedicines, Vol 9, Iss 1494, p 1494 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- MicroRNAs (miRNAs) are short non-coding RNAs involved in post-transcriptional gene regulation. Over the past years, various studies have demonstrated the role of aberrant miRNA expression in the onset of cancer. The mechanisms by which miRNA exerts its cancer-promoting or inhibitory effects are apparent through the various cancer hallmarks, which include selective proliferative advantage, altered stress response, vascularization, invasion and metastasis, metabolic rewiring, the tumor microenvironment and immune modulation; therefore, this review aims to highlight the association between miRNAs and the various cancer hallmarks by dissecting the mechanisms of miRNA regulation in each hallmark separately. It is hoped that the information presented herein will provide further insights regarding the role of cancer and serve as a guideline to evaluate the potential of microRNAs to be utilized as biomarkers and therapeutic targets on a larger scale in cancer research.
- Subjects :
- Regulation of gene expression
Tumor microenvironment
QH301-705.5
biomarkers
Medicine (miscellaneous)
Cancer
Review
Immune modulation
Biology
therapeutic targets
medicine.disease
General Biochemistry, Genetics and Molecular Biology
Metastasis
Fight-or-flight response
microRNA (miRNA)
microRNA
medicine
Cancer research
Cancer biology
Biology (General)
gene regulation
cancer biology
Subjects
Details
- ISSN :
- 22279059
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Biomedicines
- Accession number :
- edsair.doi.dedup.....d99d51a6353d958027d3f30ef2e35a16
- Full Text :
- https://doi.org/10.3390/biomedicines9101494