Back to Search Start Over

Footprints of microRNAs in Cancer Biology

Authors :
Adam Azlan
Mot Yee Yik
Aliaa Arina Rosli
Khor Kang Zi
Narazah Mohd Yusoff
Yaashini Rajasegaran
Emmanuel Jairaj Moses
Source :
Biomedicines, Biomedicines, Vol 9, Iss 1494, p 1494 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

MicroRNAs (miRNAs) are short non-coding RNAs involved in post-transcriptional gene regulation. Over the past years, various studies have demonstrated the role of aberrant miRNA expression in the onset of cancer. The mechanisms by which miRNA exerts its cancer-promoting or inhibitory effects are apparent through the various cancer hallmarks, which include selective proliferative advantage, altered stress response, vascularization, invasion and metastasis, metabolic rewiring, the tumor microenvironment and immune modulation; therefore, this review aims to highlight the association between miRNAs and the various cancer hallmarks by dissecting the mechanisms of miRNA regulation in each hallmark separately. It is hoped that the information presented herein will provide further insights regarding the role of cancer and serve as a guideline to evaluate the potential of microRNAs to be utilized as biomarkers and therapeutic targets on a larger scale in cancer research.

Details

ISSN :
22279059
Volume :
9
Database :
OpenAIRE
Journal :
Biomedicines
Accession number :
edsair.doi.dedup.....d99d51a6353d958027d3f30ef2e35a16
Full Text :
https://doi.org/10.3390/biomedicines9101494