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Narcotic and narcotic antagonist analgesics: their effect on rat brain monoamine oxidase in vitro
- Source :
- Toxicology and applied pharmacology. 24(2)
- Publication Year :
- 1973
-
Abstract
- Morphine, codeine, normorphine, norcodeine, nalorphine, methadone, pentazocine, cyclazocine, meperidine and levallorphan were tested in vitro for activity as inhibitors of rat brain monoamine oxidase. Beta-phenylisopropylhydrazine and chlorpromazine were used, respectively, as strong and weak inhibitors to define the upper and lower limits of inhibitory activity. All test compounds, with the exception of methadone, were found to be weaker monoamine oxidase inhibitors than chlorpromazine. The log dose-response curve for methadone stretches across four orders of magnitude in concentration and, at low molar concentrations, the monoamine oxidase inhibitory activity of methadone is equivalent to the monoamine oxidase inhibitory activity of betaphenylisopropylhydrazine at equally low concentrations.
- Subjects :
- Pharmacology
Normorphine
Narcotics
Analgesics
Monoamine Oxidase Inhibitors
Dose-Response Relationship, Drug
Chemistry
Narcotic antagonist
Monoamine oxidase
Chlorpromazine
Narcotic Antagonists
Brain
Toxicology
Rats
Norcodeine
Pentazocine
Levallorphan
medicine
Animals
Female
Cyclazocine
Monoamine Oxidase
medicine.drug
Subjects
Details
- ISSN :
- 0041008X
- Volume :
- 24
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Toxicology and applied pharmacology
- Accession number :
- edsair.doi.dedup.....d9adc01e793285c3bde6742ccd593e9f