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Copper-catalyzed three-component synthesis of pyrrole-substituted 1,2-dihydroisoquinolines
- Publication Year :
- 2022
- Publisher :
- Taylor & Francis, 2022.
-
Abstract
- A general approach to the synthesis of 1,3-disubstituted-1,2-dihydroisoquinolines was achieved with pyrrole and various electron withdrawing groups as substituents. CuAAC reaction on enynes yielded the resulting 1,2,3-triazole which spontaneously decomposed to the corresponding ketenimine. Nucleophilic attack by pyrrole and subsequent intramolecular Aza-Michael cyclization generated 1,2-dihydroisoquinolines in moderate to good yields. The optimized conditions allow for a range of substituents with excellent reproducibility.
- Subjects :
- Organic Chemistry
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d9d15f46a5697d951c2cb72d14a77d58
- Full Text :
- https://doi.org/10.6084/m9.figshare.19360759