SARS-CoV-2 infection does not induce HIV viral escape in Central Nervous System: a case series

Highlights • Impact of coinfection with SARS-CoV-2 on HIV replication in CNS is unknown. • SARS-CoV-2 could alter the BBB permeability and cause a CNS HIV escape. • Few symptoms during COVID-19 suggest a contained inflammatory response in CNS/plasma. • Poor immunological recovery might contribute to avoid immune-pathogenetic processes.
We report two cases of HIV positive patients with COVID-19 infection and a recent diagnosis of opportunistic infections of central nervous system (CNS). We investigated the potential impact of coinfection with SARS-CoV-2 on HIV replication in CNS.