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Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education

Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education

Authors :
I.S.M. van der Wurff
Trygve Bergeland
R.H.M. de Groot
Paul A. Kirschner
Ruslan Leontjevas
Maurice P. Zeegers
C. von Schacky
RS: NUTRIM - R3 - Respiratory & Age-related Health
RS: CAPHRI - R5 - Optimising Patient Care
Complexe Genetica
RS-Theme Biopsychology of Learning
Department FEEEL
RS-Research Line Fostering Effective, Efficient and Enjoyable Learning (FEEEL) (part of WO program)
Section Methodology & Statistics
RS-Research Program The Interaction between Implicit and Explicit Strategies for Behaviour (IIESB)
Distinguished University Professors
RS-Research Line Methodology & statistics (part of IIESB program)
Source :
European Journal of Nutrition, 58, 4, pp. 1429-1439, European Journal of Nutrition, European Journal of Nutrition, 58(4), 1429-1439. Springer, van der Wurff, I S M, Von Schacky, C, Bergeland, T, Leontjevas, R, Zeegers, M, Kirschner, P A & de Groot, R H M 2019, ' Exploring the association between whole blood Omega-3 Index, DHA, EPA, DHA, AA and n-6 DPA, and depression and self-esteem in adolescents of lower general secondary education ', European Journal of Nutrition, vol. 58, no. 4, pp. 1429–1439 . https://doi.org/10.1007/s00394-018-1667-4, European Journal of Nutrition, 58, 1429-1439, European Journal of Nutrition, 58(4). D. Steinkopff-Verlag
Publication Year :
2019

Abstract

PurposeDepression is common in adolescents and long-chain polyunsaturated fatty acids (LCPUFA) are suggested to be associated with depression. However, research in adolescents is limited. Furthermore, self-esteem has never been studied in relation to LCPUFA. The objective here was to determine associations of depression and self-esteem with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), Omega-3 Index (O3I), n-6 docosapentaenoic acid (n-6 DPA, also called Osbond acid, ObA), n-3 docosapentaenoic acid (DPA), and arachidonic acid (AA) concentrations in blood of adolescents attending lower general secondary education (LGSE).MethodsBaseline cross-sectional data from a krill oil supplementation trial in adolescents attending LGSE with an O3I ≤ 5% were analysed using regression models built with the BayesFactor package in R. Fatty acids and O3I were determined in blood. Participants filled out the Centre for Epidemiologic Studies Depression (CES-D) scale and the Rosenberg Self-Esteem scale (RSE).ResultsScores indicative of depression (CES-D ≥ 16) were found in 29.4% of the respondents. Of all fatty acids, we found extreme evidence [Bayes factor (BF) > 100] for a weak negative association between ObA and depression score [− 0.16; 95% credible interval (CI) − 0.28 to − 0.04; BF10 = 245], and substantial evidence for a weak positive association between ObA and self-esteem score (0.09; 95% CI, − 0.03 to 0.20; BF10 = 4). When all fatty acids were put in one model as predictors of CES-D or RSE, all of the 95% CI contained 0, i.e., no significant association.ConclusionNo evidence was found for associations of DHA, EPA and O3I with depression or self-esteem scores in LGSE adolescents with O3I ≤ 5%. The associations of higher ObA status with lower depression and higher self-esteem scores warrant more research.

Details

ISSN :
14366207
Volume :
58
Database :
OpenAIRE
Journal :
European Journal of Nutrition
Accession number :
edsair.doi.dedup.....da0fd9a87a85e50be40946d5d182376d
Full Text :
https://doi.org/10.1007/s00394-018-1667-4