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Natural macrocyclic molecules have a possible limited structural diversity

Authors :
Orrette R. Wauchope
Frank W. Grasso
Paul Haberfield
Nicola S. Farina
Mo Qi
Aaron T. Frank
Nahed Sawwan
Edyta M. Brzostowska
Alexander Greer
Wang Chan
Source :
Molecular Diversity. 11:115-118
Publication Year :
2007
Publisher :
Springer Science and Business Media LLC, 2007.

Abstract

This paper examines ring size patterns of natural product macrocycles. Evidence is presented that natural macrocycles containing 14-, 16-, and 18-membered rings are of frequent occurrence based on a data mining study. The results raise a question about the limited diversity of macrocycle ring sizes and the nature of the constraints that may cause them. The data suggest that the preference bears no relationship to the odd-even frequency in natural fatty acids. The trends reported here, along with those reported previously (Wessjohann et al. (2005) Mol Divers 9:171), may be generalized to better understand the possible structure preferences of natural macrocycles.

Details

ISSN :
1573501X and 13811991
Volume :
11
Database :
OpenAIRE
Journal :
Molecular Diversity
Accession number :
edsair.doi.dedup.....da4c7257cf8687bddc67265ee4e644ce
Full Text :
https://doi.org/10.1007/s11030-007-9065-5