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Effects of herbal mixture extracts on obesity in rats fed a high-fat diet
- Source :
- Journal of Food and Drug Analysis, Vol 24, Iss 3, Pp 594-601 (2016)
- Publication Year :
- 2016
- Publisher :
- The Journal of Food and Drug Analysis (JFDA), Food and Drug Administration, Taiwan (TFDA), 2016.
-
Abstract
- The aim of this study was to investigate and compare the effects of three herbal mixture extracts on obesity induced by high-fat diet (HFD) in rats. The prescriptions— Pericarpium citri reticulatae and Fructus crataegi —were used as matrix components and mixed with Ampelopsis grossedentata , Salvia miltiorrhiza , and epigallocatechin-3-gallate (EGCG) to form T1, T2, and T3 complexes, respectively. Results revealed that HFD feeding significantly increased body weight gain, fat deposition, plasma lipid profiles, hepatic lipid accumulation, and hepatic vacuoles formation, but decreased plasma levels of adiponectin in rats. Only the T1 complex showed the tendency, although not significantly so, for decreased HFD-induced body weight gain. T1 and T3 complexes significantly reduced HFD-induced fat deposition, and plasma levels of triglyceride, total cholesterol, and low-density lipoprotein cholesterol. Only the T1 complex significantly increased HFD-reduced adiponectin levels in plasma, but decreased HFD-increased triglyceride content in liver tissues. All complexes effectively inhibited HFD-induced vacuoles formation. The content of dihydromyricetin, salvianolic acid B, and EGCG in T1, T2, and T3 complexes was 18.25 ± 0.07%, 22.20 ± 0.10%, and 18.86 ± 0.04%, respectively. In summary, we demonstrated that herbal mixture extracts, especially T1 complex, exhibit antiobesity activity in HFD-fed rats.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
ved/biology.organism_classification_rank.species
lcsh:TX341-641
Vacuole
Diet, High-Fat
Salvia miltiorrhiza
Catechin
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Animals
Obesity
herbal mixture extracts
Pharmacology
Adiponectin
Triglyceride
ved/biology
high fat diet
lcsh:RM1-950
nutritional and metabolic diseases
food and beverages
Plasma levels
medicine.disease
Rats
lcsh:Therapeutics. Pharmacology
030104 developmental biology
Endocrinology
Fat diet
chemistry
030220 oncology & carcinogenesis
lipids (amino acids, peptides, and proteins)
Anti-Obesity Agents
Ampelopsis grossedentata
lcsh:Nutrition. Foods and food supply
Food Science
Subjects
Details
- ISSN :
- 10219498
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Food and Drug Analysis
- Accession number :
- edsair.doi.dedup.....da5457352a7969f2c092f75b79f191b6