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Altered microRNAs expression in T cells of patients with SLE involved in the lack of vitamin D
- Source :
- Oncotarget
- Publication Year :
- 2017
- Publisher :
- Impact Journals, LLC, 2017.
-
Abstract
- // Dao-Jun Chen 1, 2 , Lan-Ju Li 1, 2 , Xiao-Ke Yang 1, 2 , Tao Yu 1, 2 , Rui-Xue Leng 1, 2 , Hai-Feng Pan 1, 2 and Dong-Qing Ye 1, 2 1 Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China 2 Anhui Province Key Laboratory of Major Autoimmune Diseases, Hefei, Anhui, China Correspondence to: Dong-Qing Ye, email: ydqahmu@gmail.com , ydq@ahmu.edu.cn Keywords: microRNA, vitamin D, SLE, T cells Received: August 15, 2016 Accepted: May 31, 2017 Published: July 07, 2017 ABSTRACT Vitamin D has been recognized as a potent immunomodulator and its deficiency is common in different population groups including patients with SLE. As miRNAs regulation plays a significant role in SLE, the present study aimed to evaluate the association between vitamin D status and miRNAs levels in patients with SLE. The serum concentrations of vitamin D (25-hydroxyvitamin D) and the levels of six miRNAs in T cells from patients with SLE were measured in 42 SLE cases and 48 healthy controls. Vitamin D treatment was also performed in isolated and cultured T cells from SLE patients in different times and doses. Vitamin D insufficiency (25-hydroxyvitamin D concentration
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Population
SLE
T cells
vitamin D
vitamin D deficiency
03 medical and health sciences
0302 clinical medicine
microRNA
Epidemiology
Vitamin D and neurology
Medicine
education
030203 arthritis & rheumatology
education.field_of_study
business.industry
Significant difference
Serum concentration
medicine.disease
In vitro
030104 developmental biology
Oncology
Immunology
business
Research Paper
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....da5adba255d041324cf3f3f1b073ac46