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A comprehensive evaluation of the toxicology of experimental cigarettes manufactured with banded papers
- Source :
- Inhalation toxicology. 25
- Publication Year :
- 2013
-
Abstract
- To comply with state requirements, cigarette manufacturers have added low-permeability bands to the cigarette paper. These bands can extinguish the cigarette when it is no longer being puffed by a smoker.This study was conducted to evaluate the toxicology resulting from the addition of different types of bands to experimental cigarettes.A battery of assays that are typically used in toxicology studies with cigarette smoke, namely smoke chemistry, in vitro mutagenicity and cytotoxicity, and inhalation studies with rats, were used to evaluate different band characteristics added to cigarette paper.Although differences in the amount of band material was associated with an increase in some metals measured in mainstream tobacco smoke, it was not dose responsive to any band design parameter (base paper permeability, band width, band spacing, band chalk amount, or citrate). Occasional, minor differences were produced by the different types of bands; overall, there was no increased toxicity.Although there were increases and decreases in some mainstream smoke constituents, the in vitro and in vivo testing performed demonstrated that low-permeability bands on cigarettes do not modify the toxicity of smoke inhaled by smokers.
- Subjects :
- Male
Paper
Tobacco chemistry
Materials science
BALB 3T3 Cells
Cell Survival
Health, Toxicology and Mutagenesis
Toxicology
Tobacco smoke
Permeability
Toxicology studies
Rats, Sprague-Dawley
Mice
Random Allocation
Flax
Smoke
Materials Testing
Tobacco
Toxicity Tests
Cigarette smoke
Animals
Cellulose
Inhalation Exposure
Mutagenicity Tests
Tobacco Products
Rats
Specific Pathogen-Free Organisms
Sprague dawley
Consumer Product Safety
Band width
Tobacco Smoke Pollution
Mutagenicity Test
Mutagens
Subjects
Details
- ISSN :
- 10917691
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Inhalation toxicology
- Accession number :
- edsair.doi.dedup.....da756c1780c7384e69a69b0a9e219bde