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Glioblastoma quo vadis : Will migration and invasiveness reemerge as therapeutic targets?
- Source :
- Cancer Treatment Reviews, Cancer Treatment Reviews, 2018, 68, pp.145-154. ⟨10.1016/j.ctrv.2018.06.017⟩, Cancer Treatment Reviews, WB Saunders, 2018, 68, pp.145-154. ⟨10.1016/j.ctrv.2018.06.017⟩, Cancer treatment reviews, 68
- Publication Year :
- 2018
- Publisher :
- HAL CCSD, 2018.
-
Abstract
- Purpose: The purpose of the current review is to highlight, on one hand, the fact that the migratory pattern of glioma cells is the major obstacle to combat them with chemotherapy, and on the other one, the new treatment strategies to overcome this obstacle. Methods: This review surveys several membrane and extracellular molecules involved in glioma cell migration, invasiveness and resistance to apoptosis. Results: This review focuses on signaling pathways implicated in the positive regulation of glioblastoma cell migration, including glutamate and ion channel networks, microtubes and membrane-derived extracellular vesicles (EV) containing microRNAs. Glioma cells release glutamate to the extracellular matrix, inducing neuronal cell death, which may facilitate glioma growth and invasion. Glioma cell migration and invasion are further facilitated through ion channels and transporters that modify cellular volume. Microtubes and EV promote connections and communication among glioma cells and with the microenvironment and are associated with progression and resistance to therapy. Potential therapies linked to these pathways for glioblastoma are being developed. Conclusion: Our view is evolving from an intracellular view of the complex intracellular signaling pathways to one of orchestral machinery, including connections between heterogeneous tumoral and nontumoral cells and with the microenvironment through channels, microtubes, and extracellular miRNA, generating different signals at different times. All of these elements give rise to a new perspective for the treatment of glioblastoma.<br />SCOPUS: re.j<br />info:eu-repo/semantics/published
- Subjects :
- 0301 basic medicine
Programmed cell death
[SDV]Life Sciences [q-bio]
610 Medicine & health
Extracellular matrix
03 medical and health sciences
Cell Movement
Glioma
microRNA
Extracellular
2741 Radiology, Nuclear Medicine and Imaging
Animals
Humans
Medicine
Neoplasm Invasiveness
Radiology, Nuclear Medicine and imaging
Imagerie médicale, radiologie, tomographie
neoplasms
Ion channel
Brain Neoplasms
business.industry
General Medicine
medicine.disease
10040 Clinic for Neurology
3. Good health
Cell biology
[SDV] Life Sciences [q-bio]
Cancérologie
030104 developmental biology
Oncology
2730 Oncology
Signal transduction
Glioblastoma
business
Intracellular
Subjects
Details
- Language :
- English
- ISSN :
- 03057372
- Database :
- OpenAIRE
- Journal :
- Cancer Treatment Reviews, Cancer Treatment Reviews, 2018, 68, pp.145-154. ⟨10.1016/j.ctrv.2018.06.017⟩, Cancer Treatment Reviews, WB Saunders, 2018, 68, pp.145-154. ⟨10.1016/j.ctrv.2018.06.017⟩, Cancer treatment reviews, 68
- Accession number :
- edsair.doi.dedup.....da912d6ba449ba017090a8d8966833ba