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Relationship between PPAR‐γ gene polymorphisms and ischemic stroke risk: A meta‐analysis
- Source :
- Brain and Behavior, Vol 11, Iss 12, Pp n/a-n/a (2021), Brain and Behavior
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background Published researches have suggested some associations between PPAR‐γ and ischemic stroke (IS) development. This meta‐analysis was conducted to evaluate the association between PPAR‐γ gene polymorphisms and IS risk. Materials and methods A systematic search was conducted in PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases. The pooled association of odd ratios (ORs) and its 95% confidence interval (CI) was calculated to assess the IS risk of PPAR‐γ rs1801282 C/G and rs3856806 C/T polymorphisms. Furthermore, the heterogeneity test, cumulative analyses, sensitivity analyses, and publication bias were conducted. Result Sixteen publications with 3786 cases and 5343 controls were identified. Overall findings indicated that rs1801282 C/G polymorphism may be associated with an increased risk for IS (GG vs. CC: OR = 2.17 95%CI = 1.09–4.35, p = .03, I 2 = 0%; GG vs. CC+CG: OR = 2.15, 95%CI = 1.07–4.32, p = .03, I 2 = 0%). The similar results were also found in the subgroup analysis. In addition, no significant association was observed between rs3856806 C/T polymorphism and IS risk. Conclusion In conclusion, our study showed that PPAR‐γ rs1801282 C/G polymorphism probably plays an important role in IS occurrence. The result should be verified with more studies in the future.<br />Ischemic strokes (IS) are one of the most common diseases resulting in disabilities and death among adults. Our meta‐analysis indicated that the individuals with G mutation of rs1801282 C/G polymorphism would face an increased risk of IS. But there was no significant association between rs3856806 C/T polymorphism and IS risk.
- Subjects :
- Oncology
medicine.medical_specialty
Peroxisome proliferator-activated receptor
Subgroup analysis
Neurosciences. Biological psychiatry. Neuropsychiatry
Polymorphism, Single Nucleotide
polymorphism
Behavioral Neuroscience
Polymorphism (computer science)
Internal medicine
medicine
Odds Ratio
Humans
Genetic Predisposition to Disease
Stroke
Gene
Ischemic Stroke
chemistry.chemical_classification
business.industry
Publication bias
Original Articles
medicine.disease
stroke
Confidence interval
PPAR gamma
chemistry
meta‐analysis
Meta-analysis
Original Article
PPAR‐γ
business
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 21623279
- Volume :
- 11
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Brain and Behavior
- Accession number :
- edsair.doi.dedup.....daa609a606860e956c9e77ccb845a14f