Back to Search
Start Over
Calcineurin Inhibitor-Based Immunosuppression and COVID-19: Results from a Multidisciplinary Cohort of Patients in Northern Italy
- Source :
- Microorganisms, Microorganisms, Vol 8, Iss 977, p 977 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- The role of immunosuppression in SARS-CoV-2-related disease (COVID-19) is a matter of debate. We here describe the course and the outcome of COVID-19 in a cohort of patients undergoing treatment with calcineurin inhibitors. In this monocentric cohort study, data were collected from the COVID-19 outbreak in Italy up to 28 April 2020. Patients were followed at our hospital for solid organ transplantation or systemic rheumatic disorders (RMDs) and were on calcineurin inhibitor (CNI)-based therapy. Selected patients were referred from the North of Italy. The aim of our study was to evaluate the clinical course of COVID-19 in this setting. We evaluated 385 consecutive patients (220 males, 57%; median age 61 years, IQR 48–69); 331 (86%) received solid organ transplantation and 54 (14%) had a RMD. CNIs were the only immunosuppressant administered in 47 patients (12%). We identified 14 (4%) COVID-19 patients, all transplanted, mainly presenting with fever (86%) and diarrhea (71%). Twelve patients were hospitalized and two of them died, both with severe comorbidities. No patients developed acute respiratory distress syndrome or infectious complications. The surviving 10 patients are now fully recovered. The clinical course of COVID-19 patients on CNIs is generally mild, and the risk of superinfection seems low.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
medicine.medical_treatment
Disease
030230 surgery
medicine.disease_cause
Microbiology
03 medical and health sciences
0302 clinical medicine
Virology
Internal medicine
medicine
lcsh:QH301-705.5
solid organ transplantation
business.industry
Communication
Outbreak
COVID-19
Immunosuppression
calcineurin inhibitors
Calcineurin
Diarrhea
030104 developmental biology
lcsh:Biology (General)
Superinfection
Cohort
rheumatic diseases
medicine.symptom
business
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 20762607
- Volume :
- 8
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Microorganisms
- Accession number :
- edsair.doi.dedup.....dac7b36ee7c7fcab3a0e0c742716ba49