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Gut Microbial Metabolites in Parkinson’s Disease: Implications of Mitochondrial Dysfunction in the Pathogenesis and Treatment
- Source :
- Molecular Neurobiology
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- The search for therapeutic targets for Parkinson’s disease (PD) is hindered by the incomplete understanding of the pathophysiology of the disease. Mitochondrial dysfunction is an area with high potential. The neurobiological signaling connections between the gut microbiome and the central nervous system are incompletely understood. Multiple lines of evidence suggest that the gut microbiota participates in the pathogenesis of PD. Gut microbial dysbiosis may contribute to the loss of dopaminergic neurons through mitochondrial dysfunction. The intervention of gut microbial metabolites via the microbiota-gut-brain axis may serve as a promising therapeutic strategy for PD. In this narrative review, we summarize the potential roles of gut microbial dysbiosis in PD, with emphasis on microbial metabolites and mitochondrial function. We then review the possible ways in which microbial metabolites affect the central nervous system, as well as the impact of microbial metabolites on mitochondrial dysfunction. We finally discuss the possibility of gut microbiota as a therapeutic target for PD.
- Subjects :
- 0301 basic medicine
Nervous system
Microbial metabolites
Parkinson's disease
Ubiquitin-Protein Ligases
Central nervous system
Neuroscience (miscellaneous)
Gut microbiota
Disease
Gut flora
digestive system
Article
Pathogenesis
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Brain-Gut Axis
medicine
Animals
Humans
biology
Probiotics
Dopaminergic
Brain
Parkinson Disease
Fecal Microbiota Transplantation
Microbiota-gut-brain axis
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
Mitochondria
Treatment Outcome
030104 developmental biology
medicine.anatomical_structure
Neurology
Immunology
Parkinson’s disease
Dysbiosis
Mitochondrial dysfunction
030217 neurology & neurosurgery
Function (biology)
Subjects
Details
- ISSN :
- 15591182 and 08937648
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Molecular Neurobiology
- Accession number :
- edsair.doi.dedup.....dad82476c443f71c0edd48dd0fe1d61a