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Cervical Precancer Risk in HIV-Infected Women Who Test Positive for Oncogenic Human Papillomavirus Despite a Normal Pap Test

Cervical Precancer Risk in HIV-Infected Women Who Test Positive for Oncogenic Human Papillomavirus Despite a Normal Pap Test

Authors :
Xiaonan Xue
Alexandra M. Levine
Kathryn Anastos
Lisa Flowers
Philip E. Castle
Howard D. Strickler
Robert D. Burk
L. Stewart Massad
Lisa Rahangdale
Isam-Eldin Eltoum
Gypsyamber D'Souza
Nancy A. Hessol
Xianhong Xie
Howard Minkoff
Christine Colie
Margaret A. Fischl
Joel M. Palefsky
Marla J. Keller
Source :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 61, iss 10
Publication Year :
2015
Publisher :
The University of North Carolina at Chapel Hill University Libraries, 2015.

Abstract

BACKGROUND Determining cervical precancer risk among human immunodeficiency virus (HIV)-infected women who despite a normal Pap test are positive for oncogenic human papillomavirus (oncHPV) types is important for setting screening practices. METHODS A total of 2791 HIV-infected and 975 HIV-uninfected women in the Women's Interagency HIV Study were followed semiannually with Pap tests and colposcopy. Cumulative risks of cervical intraepithelial neoplasia grade 2 or greater (CIN-2+; threshold used for CIN treatment) and grade 3 or greater (CIN-3+; threshold to set screening practices) were measured in HIV-infected and HIV-uninfected women with normal Pap tests, stratified by baseline HPV results, and also in HIV-infected women with a low-grade squamous intraepithelial lesion (LSIL; benchmark indication for colposcopy). RESULTS At baseline, 1021 HIV-infected and 518 HIV-uninfected women had normal Pap tests, of whom 154 (15%) and 27 (5%), respectively, tested oncHPV positive. The 5-year CIN-2+ cumulative risk in the HIV-infected oncHPV-positive women was 22% (95% confidence interval [CI], 9%-34%), 12% (95% CI, 0%-22%), and 14% (95% CI, 2%-25%) among those with CD4 counts

Details

Language :
English
Database :
OpenAIRE
Journal :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 61, iss 10
Accession number :
edsair.doi.dedup.....daf7dcfb7c3343fd529b51b888392791
Full Text :
https://doi.org/10.17615/xdja-9660