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Cervical Precancer Risk in HIV-Infected Women Who Test Positive for Oncogenic Human Papillomavirus Despite a Normal Pap Test
Cervical Precancer Risk in HIV-Infected Women Who Test Positive for Oncogenic Human Papillomavirus Despite a Normal Pap Test
- Source :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 61, iss 10
- Publication Year :
- 2015
- Publisher :
- The University of North Carolina at Chapel Hill University Libraries, 2015.
-
Abstract
- BACKGROUND Determining cervical precancer risk among human immunodeficiency virus (HIV)-infected women who despite a normal Pap test are positive for oncogenic human papillomavirus (oncHPV) types is important for setting screening practices. METHODS A total of 2791 HIV-infected and 975 HIV-uninfected women in the Women's Interagency HIV Study were followed semiannually with Pap tests and colposcopy. Cumulative risks of cervical intraepithelial neoplasia grade 2 or greater (CIN-2+; threshold used for CIN treatment) and grade 3 or greater (CIN-3+; threshold to set screening practices) were measured in HIV-infected and HIV-uninfected women with normal Pap tests, stratified by baseline HPV results, and also in HIV-infected women with a low-grade squamous intraepithelial lesion (LSIL; benchmark indication for colposcopy). RESULTS At baseline, 1021 HIV-infected and 518 HIV-uninfected women had normal Pap tests, of whom 154 (15%) and 27 (5%), respectively, tested oncHPV positive. The 5-year CIN-2+ cumulative risk in the HIV-infected oncHPV-positive women was 22% (95% confidence interval [CI], 9%-34%), 12% (95% CI, 0%-22%), and 14% (95% CI, 2%-25%) among those with CD4 counts
- Subjects :
- Microbiology (medical)
Adult
medicine.medical_specialty
Multivariate analysis
Genotype
viruses
Cervical precancer
cervical cancer screening
HIV Infections
Cervical intraepithelial neoplasia
Cervical Cancer
Medical and Health Sciences
Microbiology
Risk Assessment
Clinical Research
Medicine
2.1 Biological and endogenous factors
2.2 Factors relating to the physical environment
Humans
Pap test
Prospective Studies
Human papillomavirus
Aetiology
human papillomavirus
Cancer
Gynecology
Colposcopy
Human papillomavirus 16
medicine.diagnostic_test
business.industry
Prevention
Papillomavirus Infections
HIV
virus diseases
Biological Sciences
medicine.disease
Uterine Cervical Dysplasia
Confidence interval
female genital diseases and pregnancy complications
Squamous intraepithelial lesion
Infectious Diseases
Sexually Transmitted Infections
HIV/AIDS
Female
business
Infection
Precancerous Conditions
Papanicolaou Test
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 61, iss 10
- Accession number :
- edsair.doi.dedup.....daf7dcfb7c3343fd529b51b888392791
- Full Text :
- https://doi.org/10.17615/xdja-9660