Back to Search
Start Over
Machine perfusion versus cold storage of kidneys derived from donation after cardiac death: a meta-analysis
- Source :
- PLoS ONE, PLoS ONE, Vol 8, Iss 3, p e56368 (2013)
- Publication Year :
- 2012
-
Abstract
- BACKGROUND: In response to the increased organ shortage, organs derived from donation after cardiac death (DCD) donors are becoming an acceptable option once again for clinical use in transplantation. However, transplant outcomes in cases where DCD organs are used are not as favorable as those from donation after brain death or living donors. Different methods of organ preservation are a key factor that may influence the outcomes of DCD kidney transplantation. METHODS: We compared the transplant outcomes in patients receiving DCD kidneys preserved by machine perfusion (MP) or by static cold storage (CS) preservation by conducting a meta-analysis. The MEDLINE, EMBASE and Cochrane Library databases were searched. All studies reporting outcomes for MP versus CS preserved DCD kidneys were further considered for inclusion in this meta-analysis. Odds ratios and 95% confidence intervals (CI) were calculated to compare the pooled data between groups that were transplanted with kidneys that were preserved by MP or CS. RESULTS: Four prospective, randomized, controlled trials, involving 175 MP and 176 CS preserved DCD kidney transplant recipients, were included. MP preserved DCD kidney transplant recipients had a decreased incidence of delayed graft function (DGF) with an odd ration of 0.56 (95% CI = 0.36-0.86, P = 0.008) compared to CS. However, no significant differences were seen between the two technologies in incidence of primary non-function, one year graft survival, or one year patient survival. CONCLUSIONS: MP preservation of DCD kidneys is superior to CS in terms of reducing DGF rate post-transplant. However, primary non-function, one year graft survival, and one year patient survival were not affected by the use of MP or CS for preservation.
- Subjects :
- medicine.medical_specialty
Anatomy and Physiology
Clinical Research Design
Biomedical Engineering
Cold storage
lcsh:Medicine
Bioengineering
Brain damage
Kidney
Engineering
Cause of Death
medicine
Odds Ratio
Humans
Intensive care medicine
lcsh:Science
Biology
Kidney transplantation
Cause of death
Cryopreservation
Machine perfusion
Multidisciplinary
business.industry
lcsh:R
Graft Survival
Odds ratio
Organ Preservation
Renal System
medicine.disease
Kidney Transplantation
Tissue Donors
Transplantation
Death
Patient Outcome Assessment
Perfusion
medicine.anatomical_structure
Transplant Surgery
Nephrology
Medicine
lcsh:Q
Surgery
medicine.symptom
Meta-Analyses
business
Research Article
Biotechnology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 8
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....db0738f655d43951ccc895a59f49f065