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Air pollution exposure affects circulating white blood cell counts in healthy subjects: the role of particle composition, oxidative potential and gaseous pollutants - the RAPTES project
- Source :
- Inhalation Toxicology, 26(3), 141. Informa Healthcare
- Publication Year :
- 2014
-
Abstract
- Studies have linked air pollution exposure to cardiovascular health effects, but it is not clear which components drive these effects. We examined the associations between air pollution exposure and circulating white blood cell (WBC) counts in humans. To investigate independent contributions of particulate matter (PM) characteristics, we exposed 31 healthy volunteers at five locations with high contrast and reduced correlations amongst pollutant components: two traffic sites, an underground train station, a farm and an urban background site. Each volunteer visited at least three sites and was exposed for 5 h with intermittent exercise. Exposure measurements on-site included PM mass and number concentration, oxidative potential (OP), elemental- and organic carbon, metals, O-3 and NO2. Total and differential WBC counts were performed on blood collected before and 2 and 18 h post-exposure (PE). Changes in total WBC counts (2 and 18 h PE), number of neutrophils (2 h PE) and monocytes (18 h PE) were positively associated with PM characteristics that were high at the underground site. These time-dependent changes reflect an inflammatory response, but the characteristic driving this effect could not be isolated. Negative associations were observed for NO2 with lymphocytes and eosinophils. These associations were robust and did not change after adjustment for a large suite of PM characteristics, suggesting an independent effect of NO2. We conclude that short-term air pollution exposure at real-world locations can induce changes in WBC counts in healthy subjects. Future studies should indicate if air pollution exposure-induced changes in blood cell counts results in adverse cardiovascular effects in susceptible individuals.
- Subjects :
- Male
Health, Toxicology and Mutagenesis
Air pollution exposure
SHORT-TERM EXPOSURE
Air pollution
Toxicology
medicine.disease_cause
ASTHMATIC VOLUNTEERS
chemistry.chemical_compound
Leukocyte Count
MARKERS
Leukocytes
experimental exposure
Volunteer
NITROGEN-DIOXIDE
Netherlands
oxidative potential
Air Pollutants
Inhalation Exposure
Particulates
medicine.anatomical_structure
Environmental chemistry
Female
Environmental Monitoring
Adult
white blood cells
Nitrogen Dioxide
Oxidative phosphorylation
DIESEL-EXHAUST INHALATION
Young Adult
Animal science
Ozone
White blood cell
medicine
Humans
Nitrogen dioxide
CORONARY-HEART-DISEASE
Particle Size
AIRBORNE PARTICULATE MATTER
particulate matter
Pollutant
INFLAMMATORY RESPONSE
RATE-VARIABILITY
LOS-ANGELES
Oxidative Stress
chemistry
volunteers
inflammation
Particulate Matter
cardiovascular effects
Subjects
Details
- ISSN :
- 10917691 and 08958378
- Volume :
- 26
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Inhalation toxicology
- Accession number :
- edsair.doi.dedup.....db0a8db324b619c830c76ebb31a62de5