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The effect of prenatal exposure on disposition of hexachloronaphthalene in female Wistar rats and fetal compartment
- Source :
- International Journal of Occupational Medicine and Environmental Health, Vol 31, Iss 5, Pp 685-695 (2018)
- Publication Year :
- 2018
-
Abstract
- Objectives Due to structural and toxicological similarities to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated naphthalenes (PCNs) were included in the Stockholm Convention on Persistent Organic Pollutants (POPs) in 2015. Hexachloronaphthalene (HxCN) is considered to be one of the most toxic congeners of PCNs. The objective of this study was to determine the maternal and fetal tissue concentrations of hexachloronaphthalene after a single administration. Material and methods Pregnant female Outbred Wistar rats were used for the study. The [14C]-HxCN was administered in a single oral dose of 0.3 mg/rat (150 kBq/rat) on gestational day 17 (GD17), GD18 or GD19. All dams were sacrificed on GD20. The blood and selected tissue samples taken from mothers and fetuses 24 h, 48 h or 72 h after exposure were evaluated for the distribution of HxCN. Results Maximum concentrations of HxCN in pregnant rats were found in the liver and adipose tissue. Relatively high levels of HxCN were also reported in the spleen, ovaries, adrenal glands and uterus, as well as in the sciatic nerve, brain and kidneys. Hexachloronaphthalene penetrates through the blood-brain barrier (BBB), as evidenced by twice the concentration in the brain compared to the blood concentration, and through the placental barrier, as indicated by the level of maternal-fetal compartment (placenta, amniotic fluid, litter). Among the examined fetal tissues, the highest levels of HxCN were found in the kidneys and in the brain. The concentrations in these organs were higher than that found in the maternal blood. Conclusions This paper is the first to detail the concentrations of HxCN in the maternal tissues and the transplacental transfer of the tested compound to the fetuses. The exposure of pregnant rats to HxCN results in its accumulation in the maternal liver, fat tissue, reproductive and nervous system, and particularly in the fetal brain. This demonstrates both the effective absorption and significant systemic accumulation which could lead to negative health implications. Int J Occup Med Environ Health 2018;31(5):685-695.
- Subjects :
- 0301 basic medicine
Amniotic fluid
Uterus
Administration, Oral
Adipose tissue
Physiology
lcsh:Medicine
Spleen
Naphthalenes
010501 environmental sciences
01 natural sciences
03 medical and health sciences
Fetus
hexachloronaphthalene
Pregnancy
Placenta
medicine
Animals
Tissue Distribution
Carbon Radioisotopes
Rats, Wistar
Maternal-Fetal Exchange
0105 earth and related environmental sciences
pregnant rat
business.industry
lcsh:R
Public Health, Environmental and Occupational Health
Transplacental
General Medicine
fetal compartment
polychlorinated naphthalenes
030104 developmental biology
medicine.anatomical_structure
Blood-Brain Barrier
transplacental transfer
disposition
Gestation
Female
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Occupational Medicine and Environmental Health, Vol 31, Iss 5, Pp 685-695 (2018)
- Accession number :
- edsair.doi.dedup.....db19b979d944a7dee52f545dd81a3941