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CSF/serum matrix metallopeptidase-9 ratio discriminates neuro Behçet from multiple sclerosis
- Source :
- Annals of Clinical and Translational Neurology
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- In neuro Behçet disease with multiple sclerosis‐like features, diagnosis could be challenging. Here, we studied the cerebrospinal fluid and serum inflammatory profile of 11 neuro Behçet and 21 relapsing‐remitting multiple sclerosis patients. Between the soluble factors analyzed (MMP9, TNF α, IL6, CXCL13, CXCL10, CXCL8, IFN γ, IL10, IL17, IL23, and others) we found MMP9 increased in neuro Behçet serum compared to multiple sclerosis and decreased in cerebrospinal fluid. Furthermore, neuro Behçet analysis of circulating natural killer CD56DIM subset suggests their potential involvement in increased MMP9 production. We believe that these findings may have a translational utility in clinical practice.
- Subjects :
- 030203 arthritis & rheumatology
business.industry
General Neuroscience
Multiple sclerosis
MMP9
Brief Communication
medicine.disease
eye diseases
body regions
stomatognathic diseases
03 medical and health sciences
Interleukin 10
0302 clinical medicine
Cerebrospinal fluid
Immunology
medicine
Interleukin 23
CXCL10
Neurology (clinical)
Interleukin 8
CXCL13
Brief Communications
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 23289503
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Annals of Clinical and Translational Neurology
- Accession number :
- edsair.doi.dedup.....db4816778a25f9f27b73049df95de8de