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Antiretroviral therapy abrogates association between arginase activity and HIV disease severity
- Source :
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publisher :
- Published by Elsevier Ltd.
-
Abstract
- Arginase-induced L-arginine deprivation is emerging as a key mechanism for the downregulation of immune responses. We hypothesised that arginase activity increases with disease severity in HIV-seropositive patients. Our results show that peripheral blood mononuclear cells (PBMCs) from 23 HIV-seropositive patients with low CD4+ T cell counts (≤350 cells/μl) expressed significantly more arginase compared with 21 patients with high CD4+ T cell counts. Furthermore, we found a significant association between the two principal prognostic markers used to monitor HIV disease (CD4+ T cell count and plasma viral load) and PBMC arginase activity in antiretroviral therapy naïve patients but not in patients undergoing therapy.
- Subjects :
- Male
Anti-HIV Agents
T cell
T cells
CD4 cell count
L-arginine
HIV Infections
Arginine
Peripheral blood mononuclear cell
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Immune system
Immunopathology
medicine
Humans
Immune response
030304 developmental biology
0303 health sciences
biology
Arginase
business.industry
Public Health, Environmental and Occupational Health
HIV
General Medicine
Viral Load
biology.organism_classification
3. Good health
CD4 Lymphocyte Count
Infectious Diseases
medicine.anatomical_structure
Society Meeting Paper
Lentivirus
Immunology
HIV-1
Leukocytes, Mononuclear
Parasitology
Female
Viral disease
business
Viral load
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 00359203
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Accession number :
- edsair.doi.dedup.....db5ec531480eeac2bc28a373b5f5b959
- Full Text :
- https://doi.org/10.1016/j.trstmh.2010.08.004