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Doneness preferences, meat and meat-derived heterocyclic amines intake, and N-acetyltransferase 2 polymorphisms: association with colorectal adenoma in Japanese Brazilians
- Source :
- Eur J Cancer Prev
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Intake of heterocyclic amines (HCAs) and other mutagenic compounds formed during cooking has been hypothesized to be responsible for the positive association observed between red meat and colorectal cancer. We evaluated whether well-done/very well-done preferences for various meat and fish items, higher intakes of meat and fish, and meat-derived and fish-derived HCA are associated with the risk of colorectal adenoma (CRA) in a Japanese-Brazilian population. We selected 302 patients with adenoma and 403 control individuals who underwent total colonoscopy between 2007 and 2013, and collected information on aspects of meat intake using a detailed questionnaire. We also estimated HCA intake of the study participants using an HCA database that matched the cooking methods of this population. Latent class analysis on the basis of response to doneness preferences for different cooking methods of commonly consumed meat and fish items identified four distinct subgroups. Compared with the subgroup characterized by a preference for rare/medium well-done cooking for most meat and fish items, the odds ratio of CRA for the well-done/very well-done preference subgroup was 1.19 (95% confidence interval: 0.51-2.75). High intake of mixed-meat dishes was suggestively associated inversely with CRA, whereas a high intake of poultry was associated positively with CRA. No clear association with intake of total or specific HCAs and no effect modification by N-acetyltransferase 2 acetylation genotype were observed. We found no statistically significant associations between meat and HCA intake and CRA. These findings do not support a positive association between meat and meat-derived HCA intake and the risk of CRA.
- Subjects :
- Adenoma
Adult
Male
Cancer Research
Hot Temperature
Arylamine N-Acetyltransferase
Epidemiology
Colorectal cancer
Population
Colorectal adenoma
Polymorphism, Single Nucleotide
Article
03 medical and health sciences
0302 clinical medicine
Asian People
Risk Factors
Fish Products
medicine
Humans
Genetic Predisposition to Disease
Cooking
030212 general & internal medicine
Food science
Amines
N acetyltransferase 2
education
Aged
education.field_of_study
business.industry
Public Health, Environmental and Occupational Health
food and beverages
Colonoscopy
Feeding Behavior
Odds ratio
Consumer Behavior
Middle Aged
medicine.disease
Confidence interval
Red Meat
Oncology
Case-Control Studies
030220 oncology & carcinogenesis
Japanese brazilians
Carcinogens
Red meat
Female
Colorectal Neoplasms
business
Brazil
Subjects
Details
- ISSN :
- 09598278
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- European Journal of Cancer Prevention
- Accession number :
- edsair.doi.dedup.....db5f1c0f7968cf67296be296078b29bb