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Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway
- Source :
- Scientific Reports
- Publication Year :
- 2015
- Publisher :
- Nature Publishing Group, 2015.
-
Abstract
- Natural compounds derived from medicinal plants have long been considered a rich source of novel therapeutic agents. Baicalin (Ba) is a bioactive flavonoid compound derived from the root of Scutellaria baicalensis, an herb widely used in traditional medicine for the treatment of various inflammatory diseases. In this study, we investigate the effects and mechanism of action of Ba in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Ba treatment effectively ameliorated clinical disease severity in myelin oligodendrocyte glycoprotein (MOG)35–55 peptide-induced EAE and reduced inflammation and demyelination of the central nervous system (CNS). Ba reduced infiltration of immune cells into the CNS, inhibited expression of proinflammatory molecules and chemokines and prevented Th1 and Th17 cell differentiation via STAT/NFκB signaling pathways. Further, we showed that SOCS3 induction is essential to the effects of Ba, given that the inhibitory effect of Ba on pathogenic Th17 responses was largely abolished when SOCS3 signaling was knocked down. Taken together, our findings demonstrate that Ba has significant potential as a novel anti-inflammatory agent for therapy of autoimmune diseases such as MS.
- Subjects :
- Encephalomyelitis, Autoimmune, Experimental
Multiple Sclerosis
Encephalomyelitis
Suppressor of Cytokine Signaling Proteins
Inflammation
Pharmacology
Biology
Lymphocyte Activation
Article
Proinflammatory cytokine
Myelin oligodendrocyte glycoprotein
Mice
Immune system
T-Lymphocyte Subsets
medicine
Animals
SOCS3
Flavonoids
Multidisciplinary
Anti-Inflammatory Agents, Non-Steroidal
Experimental autoimmune encephalomyelitis
NF-kappa B
Cell Differentiation
Th1 Cells
medicine.disease
biology.organism_classification
Disease Models, Animal
STAT Transcription Factors
Suppressor of Cytokine Signaling 3 Protein
biology.protein
Cytokines
Th17 Cells
Scutellaria baicalensis
Female
Inflammation Mediators
medicine.symptom
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....db7420d72c779ece2ed8de2b9edfe49e