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Overview of « druggable » alterations by histological subtypes of sarcomas and connective tissue intermediate malignancies
- Source :
- Critical Reviews in Oncology/Hematology, Critical Reviews in Oncology/Hematology, Elsevier, 2020, 150, pp.102960-. ⟨10.1016/j.critrevonc.2020.102960⟩, Critical Reviews in Oncology/Hematology, 2020, 150, pp.102960-. ⟨10.1016/j.critrevonc.2020.102960⟩
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- We summarize herein the literature data about molecular targeted therapies in sarcomas and conjunctive tissue intermediate malignancies. For each clinical setting, the level of evidence, the mechanism of action and the target are described. The two major axes include (i) identification of subgroups of tumors with druggable alteration irrespective of the histological diagnosis (e.g. NTRK), and (ii) druggable target of pathway related to the physiopathology of the tumor: denosumab and bone giant cell tumor, imatinib and soft tissue giant cell tumor, mTOR inhibitor and PECOMA.
- Subjects :
- 0301 basic medicine
[SDV]Life Sciences [q-bio]
Druggability
Connective tissue
Molecular Targeted Therapies
Antineoplastic Agents
Soft Tissue Neoplasms
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Molecular Targeted Therapy
Neoplasms, Connective Tissue
business.industry
Soft tissue
Imatinib
Sarcoma
Hematology
Pathophysiology
3. Good health
030104 developmental biology
medicine.anatomical_structure
Denosumab
Oncology
Giant cell
030220 oncology & carcinogenesis
Cancer research
Imatinib Mesylate
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 10408428
- Database :
- OpenAIRE
- Journal :
- Critical Reviews in Oncology/Hematology, Critical Reviews in Oncology/Hematology, Elsevier, 2020, 150, pp.102960-. ⟨10.1016/j.critrevonc.2020.102960⟩, Critical Reviews in Oncology/Hematology, 2020, 150, pp.102960-. ⟨10.1016/j.critrevonc.2020.102960⟩
- Accession number :
- edsair.doi.dedup.....db7cfe22304043e85d75227368fc741a