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Valve Strain Quantitation in Normal Mitral Valves and Mitral Prolapse With Variable Degrees of Regurgitation
- Source :
- JACC. Cardiovascular imaging. 14(6)
- Publication Year :
- 2020
-
Abstract
- Objectives The aim of this study was to quantitate patient-specific mitral valve (MV) strain in normal valves and in patients with mitral valve prolapse with and without significant mitral regurgitation (MR) and assess the determinants of MV strain. Background Few data exist on MV deformation during systole in humans. Three-dimensional echocardiography allows for dynamic MV imaging, enabling digital modeling of MV function in health and disease. Methods Three-dimensional transesophageal echocardiography was performed in 82 patients, 32 with normal MV and 50 with mitral valve prolapse (MVP): 12 with mild mitral regurgitation or less (MVP − MR) and 38 with moderate MR or greater (MVP + MR). Three-dimensional MV models were generated, and the peak systolic strain of MV leaflets was computed on proprietary software. Results Left ventricular ejection fraction was normal in all groups. MV annular dimensions were largest in MVP + MR (annular area: 13.8 ± 0.7 cm2) and comparable in MVP − MR (10.6 ± 1 cm2) and normal valves (10.5 ± 0.3 cm2; analysis of variance: p Conclusions MVs that exhibit prolapse have higher strain compared to normal valves, particularly in the posterior leaflet. Although higher strain is observed with worsening MR and larger valves and annuli, mitral valve leaflet thickness—and, thus, underlying MV pathology—is the most significant independent determinant of valve deformation. Future studies are needed to assess the impact of MV strain determination on clinical outcome.
- Subjects :
- medicine.medical_specialty
Mitral prolapse
Strain (injury)
Regurgitation (circulation)
030204 cardiovascular system & hematology
Ventricular Function, Left
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Mitral valve
Prolapse
medicine
Mitral valve prolapse
Humans
Radiology, Nuclear Medicine and imaging
cardiovascular diseases
Systole
Mitral regurgitation
Ejection fraction
Mitral Valve Prolapse
business.industry
Stroke Volume
medicine.disease
medicine.anatomical_structure
cardiovascular system
Cardiology
Mitral Valve
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 18767591
- Volume :
- 14
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- JACC. Cardiovascular imaging
- Accession number :
- edsair.doi.dedup.....db85a86f5672c6bd0c570b85514665ad