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Endovascular Stents and Stent-Grafts: Is Heparin Coating Desirable?
- Source :
- CardioVascular and Interventional Radiology. 23:252-255
- Publication Year :
- 2000
- Publisher :
- Springer Science and Business Media LLC, 2000.
-
Abstract
- Heparins are glycosaminoglycans that, in addition to their anticoagulant activity, have interactions with growth factors and other glycoproteins. These interactions may stimulate neointimal hyperplasia when heparin is delivered locally on stents and stent-grafts. Modifying the structure of heparin to retain anticoagulant activity while minimizing these stimulatory effects on the vascular endothelium is desirable and may be achieved by understanding the relationships between the structure and function of the various parts of the heparin molecule.
- Subjects :
- medicine.medical_specialty
Endothelium
medicine.drug_class
medicine.medical_treatment
Arterial Occlusive Diseases
Pharmacology
Prosthesis Design
Glycosaminoglycan
Blood Vessel Prosthesis Implantation
Coated Materials, Biocompatible
medicine
Animals
Humans
Radiology, Nuclear Medicine and imaging
Neointimal hyperplasia
Molecular Structure
Heparin
Polyethylene Terephthalates
business.industry
Graft Survival
Anticoagulant
Graft Occlusion, Vascular
Anticoagulants
Stent
medicine.disease
Heparin coating
Surgery
Fibroblast Growth Factors
Vascular endothelium
medicine.anatomical_structure
Stents
Endothelium, Vascular
Cardiology and Cardiovascular Medicine
business
Cell Division
medicine.drug
Subjects
Details
- ISSN :
- 1432086X and 01741551
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- CardioVascular and Interventional Radiology
- Accession number :
- edsair.doi.dedup.....db86646187d43542eea3752a7ab71366