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Relationships of Macular Pigment Optical Density With Plasma Lutein, Zeaxanthin, and Diet in an Elderly Population: The Montrachet Study
- Source :
- Investigative Ophthalmology and Visual Science 3 (57), 1160-1167. (2016), Investigative Ophthalmology & Visual Science, Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2016, 57 (3), pp.1160-1167. 〈10.1167/iovs.15-18007〉, Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2016, 57 (3), pp.1160-1167. ⟨10.1167/iovs.15-18007⟩
- Publication Year :
- 2016
- Publisher :
- Association for Research in Vision and Ophthalmology (ARVO), 2016.
-
Abstract
- International audience; PURPOSE. To investigate the association of macular pigment optical density (MPOD) with plasma lutein, zeaxanthin, and diet in an elderly population.METHODS. We conducted a population-based study, the Montrachet (Maculopathy Optic Nerve, nuTRition neurovAsCular, and HEarT disease) study, in subjects older than 75 years. The MPOD was measured by means of the two-wavelength autofluorescence technique. Plasma lutein and zeaxanthin were measured in fasting blood samples using HPLC. Food frequency consumption was assessed with self-reported food frequency questionnaires.RESULTS. Overall, 433 healthy participants (62.1% females) were included. Mean age was 82.0 +/- 3.6 years. Mean MPOD at 0.5 degrees eccentricity was 0.57 +/- 0.25 density units (DU) and was higher in women than in men (0.59 +/- 0.25 vs. 0.53 +/- 0.25, P = 0.017). The MPOD was lower in alcohol consumers than in non-alcohol consumers (0.55 +/- 0.25 vs. 0.61 +/- 0.25, P = 0.016). Median plasma lutein and zeaxanthin levels were 281.4 mu g/L and 20.0 mu g/L, respectively, and were higher in women (P = 0.010 and P = 0.003, respectively). The MPOD was positively correlated with plasma lutein and zeaxanthin (r = 0.10, P = 0.030 and r = 0.11, P = 0.027, respectively). A higher consumption of squash was associated with higher plasma lutein and zeaxanthin. Adjusting for confounders and diet revealed that MPOD was weakly associated with plasma lutein in nonsmokers (beta = 0.11, P = 0.021).CONCLUSIONS. This study suggests that plasma lutein is associated with MPOD after taking into account potential confounding factors in an elderly population.
- Subjects :
- Male
Aging
Lutein
Urban Population
Organes des sens
Visual Acuity
degeneration
eye disease
chemistry.chemical_compound
0302 clinical medicine
Macular Pigment
Macula Lutea
030212 general & internal medicine
macular pigment optical density
risk-factors
Carotenoid
Chromatography, High Pressure Liquid
Aged, 80 and over
chemistry.chemical_classification
education.field_of_study
Confounding
carotenoids
food and beverages
Middle Aged
Healthy Volunteers
supplemental lutein
lutein
zeaxanthin
diet
elderly
population-based
study
Zeaxanthin
age-related maculopathy
population-based study
Population Surveillance
Alimentation et Nutrition
Female
France
Adult
medicine.medical_specialty
prevalence
Sensory Organs
Population
03 medical and health sciences
Zeaxanthins
Internal medicine
medicine
Humans
Food and Nutrition
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
serum concentrations
education
omega-3-fatty-acids
[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology
Aged
Retrospective Studies
business.industry
Feeding Behavior
medicine.disease
sample
eye diseases
Age-related maculopathy
Endocrinology
chemistry
030221 ophthalmology & optometry
Maculopathy
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15525783 and 01460404
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Investigative Opthalmology & Visual Science
- Accession number :
- edsair.doi.dedup.....db95ae21ad5889285479361b90cf6dbd