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Gonadotrophin releasing hormone causes a biphasic secretion of luteinizing hormone and follicle stimulating hormone by cultures of rat anterior pituitary cells
- Source :
- Acta Endocrinologica. 99:44-49
- Publication Year :
- 1982
- Publisher :
- Oxford University Press (OUP), 1982.
-
Abstract
- Primary monolayer cultures of adult male rat anterior pituitary cells secreted both LH and FSH in a biphasic manner when incubated with gonadotrophin releasing hormone (GnRH). The peaks of secretion of LH and FSH were coincident; the first occurred between 15 and 30 min and the second between 1 and 3 h after the addition of GnRH. Approximately 20% of the total amount of gonadotrophins secreted in the 6 h treatment with GnRH was contained in the first peak. Inhibitors of the secretion of gonadotrophins affected LH and FSH secretion differently. Inhibin suppressed the secretion of FSH to a greater extent than that of LH, whereas testosterone and cycloheximide had a greater effect on LH. Neither phase of secretion of LH or FSH was reduced preferentially by inhibin or testosterone but the greater effect of cycloheximide was on the second phase of secretion.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Somatotropic cell
Endocrinology, Diabetes and Metabolism
Gonadotropin-releasing hormone
Gonadotropic cell
Gonadotropin-Releasing Hormone
Follicle-stimulating hormone
Endocrinology
Anterior pituitary
Pituitary Gland, Anterior
Thyrotropic cell
Internal medicine
medicine
Animals
Inhibins
Testosterone
Cycloheximide
Cells, Cultured
Chemistry
Proteins
Rats, Inbred Strains
General Medicine
Luteinizing Hormone
Rats
Testicular Hormones
medicine.anatomical_structure
Corticotropic cell
Follicle Stimulating Hormone
Luteinizing hormone
Pituitary Hormone-Releasing Hormones
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 1479683X and 08044643
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Acta Endocrinologica
- Accession number :
- edsair.doi.dedup.....db9641c1d642e61447b0977dcc6de472