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Genetics and Epigenetics of Atrial Fibrillation
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 21, Iss 5717, p 5717 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- Atrial fibrillation (AF) is known to be the most common supraventricular arrhythmia affecting up to 1% of the general population. Its prevalence exponentially increases with age and could reach up to 8% in the elderly population. The management of AF is a complex issue that is addressed by extensive ongoing basic and clinical research. AF centers around different types of disturbances, including ion channel dysfunction, Ca2+-handling abnormalities, and structural remodeling. Genome-wide association studies (GWAS) have uncovered over 100 genetic loci associated with AF. Most of these loci point to ion channels, distinct cardiac-enriched transcription factors, as well as to other regulatory genes. Recently, the discovery of post-transcriptional regulatory mechanisms, involving non-coding RNAs (especially microRNAs), DNA methylation, and histone modification, has allowed to decipher how a normal heart develops and which modifications are involved in reshaping the processes leading to arrhythmias. This review aims to provide a current state of the field regarding the identification and functional characterization of AF-related epigenetic regulatory networks
- Subjects :
- 0301 basic medicine
Population
Genome-wide association study
Review
030204 cardiovascular system & hematology
Biology
Bioinformatics
Catalysis
Ion Channels
Epigenesis, Genetic
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
microRNA
Atrial Fibrillation
Animals
Humans
Gene Regulatory Networks
Epigenetics
Physical and Theoretical Chemistry
education
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
Genetic association
Regulation of gene expression
education.field_of_study
epigenetics
Organic Chemistry
General Medicine
DNA Methylation
Computer Science Applications
Histone Code
MicroRNAs
030104 developmental biology
Histone
lcsh:Biology (General)
lcsh:QD1-999
Genetic Loci
DNA methylation
biology.protein
RNA, Long Noncoding
gene regulation
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 21
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....dbe7ad908e4381ed1dc7d397e98efa01