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Radiologic imaging of the renal parenchyma structure and function
- Source :
- Nature Reviews Nephrology. 12:348-359
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Radiologic imaging has the potential to identify several functional and/or structural biomarkers of acute and chronic kidney diseases that are useful diagnostics to guide patient management. A renal ultrasound examination can provide information regarding the gross anatomy and macrostructure of the renal parenchyma, and ultrasound imaging modalities based on Doppler or elastography techniques can provide haemodynamic and structural information, respectively. CT is also able to combine morphological and functional information, but the use of CT is limited due to the required exposure to X-ray irradiation and a risk of contrast-induced nephropathy following intravenous injection of a radio-contrast agent. MRI can be used to identify a wide range of anatomical and physiological parameters at the tissue and even cellular level, such as tissue perfusion, oxygenation, water diffusion, cellular phagocytic activity, tissue stiffness, and level of renal filtration. The ability of MRI to provide valuable information for most of these parameters within a renal context is still in development and requires more clinical experience, harmonization of technical procedures, and an evaluation of reliability and validity on a large scale.
- Subjects :
- medicine.medical_specialty
Context (language use)
030204 cardiovascular system & hematology
Kidney
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Parenchyma
Medical imaging
medicine
Animals
Humans
Parenchymal Tissue
Ultrasonography
medicine.diagnostic_test
business.industry
Kidney metabolism
Magnetic resonance imaging
Magnetic Resonance Imaging
Oxygen
medicine.anatomical_structure
Nephrology
Gross anatomy
Kidney Diseases
Elastography
Radiology
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 1759507X and 17595061
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Nature Reviews Nephrology
- Accession number :
- edsair.doi.dedup.....dbed99a28a88f0050326701a16b3c317