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Sex‐Related Differences in Patients at High Bleeding Risk Undergoing Percutaneous Coronary Intervention: A Patient‐Level Pooled Analysis From 4 Postapproval Studies
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Background Women have been associated with higher rates of recurrent events after percutaneous coronary intervention than men, possibly attributable to advanced age at presentation and greater comorbidities. These factors also put women at higher risk of bleeding, which may influence therapeutic strategies and clinical outcomes. Methods and Results We performed a patient‐level pooled analysis of 4 postapproval registries to evaluate sex‐related differences in patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention. HBR required fulfillment of at least 1 major or 2 minor criteria of the Academic Research Consortium definition. Outcomes of interest were major bleeding and major adverse cardiac events (composite of cardiac death, myocardial infarction, or definite/probable stent thrombosis). Of the total 10 502 patients, 2832 (27.0%) were women. The prevalence of HBR was higher in women compared with men (29.0% versus 20.5%, P P P =0.82) and remained consistent after adjustment (hazard ratio, 0.64; 95% CI, 0.32–1.28). Conclusions The prevalence of HBR was higher in women compared with men, with considerable differences in the distribution of criteria. Women at HBR experienced higher rates of major bleeding but similar major adverse cardiac event rates compared with men at HBR at 4 years.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Everolimus eluting stent
medicine.medical_treatment
Hemorrhage
Coronary Artery Disease
030204 cardiovascular system & hematology
Risk Assessment
03 medical and health sciences
Percutaneous Coronary Intervention
Sex Factors
0302 clinical medicine
Recurrence
Risk Factors
Internal medicine
high bleeding risk
Stent
Prevalence
medicine
sex
Humans
In patient
Registries
030212 general & internal medicine
Original Research
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Dual Anti-Platelet Therapy
Percutaneous coronary intervention
Drug-Eluting Stents
Sex related
Middle Aged
Interventional Cardiology
Treatment Outcome
Pooled analysis
major bleeding
everolimus‐eluting stent
Female
Presentation (obstetrics)
Cardiology and Cardiovascular Medicine
business
Major bleeding
Subjects
Details
- ISSN :
- 20479980
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association
- Accession number :
- edsair.doi.dedup.....dbfe046c65164cbf3d59dbe2d1fa7536