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A Standardized Composition from Extracts ofMyristica Fragrans,Astragalus Membranaceus, andPoria CocosProtects Liver from Acute Ethanol Insult
- Source :
- Journal of Medicinal Food. 19:780-788
- Publication Year :
- 2016
- Publisher :
- Mary Ann Liebert Inc, 2016.
-
Abstract
- Despite the promising advances in therapeutic discovery, there still is a major challenge in the development of a safe, effective, and economical intervention for managing alcohol-related liver disorders. In this study, we describe the potential use of "MAP," a standardized composition comprising three extracts from Myristica fragrans, Astragalus membranaceus, and Poria cocos, in ameliorating alcohol-induced acute liver toxicity. Ethanol-induced acute hepatotoxicity as an animal model of binge drinking was utilized. Mice received oral doses of MAP at 300 mg/kg for four consecutive days. Mice were orally gavaged with 50% ethanol in 12 mL/kg dosing volume following the third dose of MAP every 12 h thereafter for a total of three doses. Hepatic functional tests from serum collected at T12, and hepatic glutathione (GSH), superoxide dismutases (SODs), and triglyceride from liver homogenates were evaluated. Histopathology analysis and alcoholic steatohepatitis (ASH) scoring were also determined. Excessive increases of serum alanine aminotransferase and aspartate aminotransferase were significantly inhibited at 46.3% and 43.6%, respectively, when mice were treated with MAP. MAP replenished the depleted SOD by more than 60%, while causing significant stimulation of GSH productions. MAP showed statistically significant reduction in ballooning degeneration, vascular steatosis, cytoplasmic or nuclear condensation, and shrinkage, as well as inflammations when compared to vehicle-treated alcohol-induced liver toxicity model. Mice treated with MAP showed statistically significant reduction in ASH scoring when compared to vehicle control. Therefore, the composition MAP could be potentially utilized as an effective hepatic-detoxifying agent for the protection of liver damage caused by alcohol consumptions.
- Subjects :
- Male
0301 basic medicine
Medicine (miscellaneous)
Aspartate transaminase
Antioxidants
Myristica
Superoxide dismutase
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Blood serum
Animals
Medicine
Aspartate Aminotransferases
Biological Products
Nutrition and Dietetics
Ethanol
biology
Traditional medicine
Superoxide Dismutase
business.industry
Fatty liver
Alanine Transaminase
Astragalus Plant
Glutathione
biology.organism_classification
medicine.disease
Astragalus
030104 developmental biology
Liver
Biochemistry
chemistry
Alanine transaminase
030220 oncology & carcinogenesis
biology.protein
Myristica fragrans
Chemical and Drug Induced Liver Injury
business
Phytotherapy
Wolfiporia
Subjects
Details
- ISSN :
- 15577600 and 1096620X
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Journal of Medicinal Food
- Accession number :
- edsair.doi.dedup.....dc2af8fb3b59e30a7e24c939897db68f