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Prognosis genes in gastric adenocarcinoma identified by cross talk genes in disease-related pathways
- Source :
- Molecular Medicine Reports
- Publication Year :
- 2017
- Publisher :
- Spandidos Publications, 2017.
-
Abstract
- The aim of the present study was to investigate the prognostic value of genes that participate in the development of gastric adenocarcinoma, via exploring gene cross talk in disease-related pathways. Differentially expressed genes (DEGs) in the gastric samples were identified by analyzing the expression data downloaded from the GEO database. The DEGs were subjected to the human protein-protein interaction (PPI) network to construct the PPI network of DEGs, which was then used for the identification of key genes in cancer samples via the expression deviation score and degree in the network. A total of 635 DEGs, including 432 downregulated and 203 upregulated ones were screened in the gastric adenocarcinomas samples. The PPI network of DEGs comprised 590 DEGs and 4,299 interaction pairs. A total of 200 key genes were obtained, which were significantly enriched in six downregulated and six upregulated pathways. Cross talk genes in the connected pathways were analyzed, and the Kyoto Encyclopedia of Genes and Genomes pathways hsa00980 (Metabolism of xenobiotics by cytochrome P450) and hsa00982 (Drug metabolism) were reported to share 8 cross talk genes: ADH7, ALDH3A1, GSTA1, GSTA2, UGT2B17, UGT2B10, ADH1B and CYP2C18. Among all cross talk genes, ADH7, ALDH3A1 and CLDN3 were the most specific genes. The high- and low-risk samples identified by the prognosis model presented a remarkable difference in total survival time, indicating its robustness and sensitivity as the prognosis genes for gastric adenocarcinoma. ADH7, ALDH3A1, GSTA1, GSTA2, UGT2B17, UGT2B10, ADH1B, CYP2C18ADH7, ALDH3A1 and CLDN3 may be used as the prognosis markers and target biomarkers for chemotherapies in gastric adenocarcinoma.
- Subjects :
- 0301 basic medicine
Cancer Research
Gene regulatory network
Adenocarcinoma
Biology
Biochemistry
protein-protein interaction
03 medical and health sciences
0302 clinical medicine
Stomach Neoplasms
cross talk gene
Databases, Genetic
Protein Interaction Mapping
Genetics
Cluster Analysis
Humans
Gene Regulatory Networks
Protein Interaction Maps
KEGG
Molecular Biology
Gene
Regulation of gene expression
Oncogene
pathway
Gene Expression Profiling
CLDN3
Computational Biology
Articles
Prognosis
Survival Analysis
Molecular medicine
Gene Expression Regulation, Neoplastic
Gene expression profiling
030104 developmental biology
ROC Curve
Oncology
gastric adenocarcinomas
030220 oncology & carcinogenesis
Cancer research
Molecular Medicine
Signal Transduction
Subjects
Details
- ISSN :
- 17913004 and 17912997
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....dc31fd9a8bfb3545a0e7f4048eb2b05d