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Neurons are recruited to a memory trace based on relative neuronal excitability immediately before training
Neurons are recruited to a memory trace based on relative neuronal excitability immediately before training
- Source :
- Neuron, 83(3), 722-735. Cell Press
- Publication Year :
- 2014
-
Abstract
- SummaryMemories are thought to be sparsely encoded in neuronal networks, but little is known about why a given neuron is recruited or allocated to a particular memory trace. Previous research shows that in the lateral amygdala (LA), neurons with increased CREB are selectively recruited to a fear memory trace. CREB is a ubiquitous transcription factor implicated in many cellular processes. Which process mediates neuronal memory allocation? One hypothesis is that CREB increases neuronal excitability to bias neuronal recruitment, although this has not been shown experimentally. Here we use several methods to increase neuronal excitability and show this both biases recruitment into the memory trace and enhances memory formation. Moreover, artificial activation of these neurons alone is a sufficient retrieval cue for fear memory expression, showing that these neurons are critical components of the memory trace. These results indicate that neuronal memory allocation is based on relative neuronal excitability immediately before training.Video Abstract
- Subjects :
- Male
Neuroscience(all)
Engram
CREB
Amygdala
03 medical and health sciences
0302 clinical medicine
Memory
Conditioning, Psychological
medicine
Memory formation
Animals
Learning
Nervous System Physiological Phenomena
Cyclic AMP Response Element-Binding Protein
Transcription factor
Neuronal memory allocation
030304 developmental biology
Neurons
0303 health sciences
Neuronal Plasticity
biology
General Neuroscience
Fear
medicine.anatomical_structure
nervous system
biology.protein
Memory consolidation
Female
Neuron
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10974199 and 08966273
- Volume :
- 83
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Neuron
- Accession number :
- edsair.doi.dedup.....dc59ed10ed29813be1ae4da9d7450b7d