Utilization of Molybdenum- and Palladium-Catayzed Dynamic Kinetic Asymmetric Transformations for the Preparation of Tertiary and Quaternary Stereogenic Centers: A Concise Synthesis of Tipranavir

Tipranavir, an important antiviral agent in clinical development for the treatment of HIV, is synthesized in 15 linear steps from readily available starting materials in 25% overall yield by utilizing Pd- and Mo-catalyzed DYKAT reactions to control the quaternary and tertiary stereogenic centers, respectively.