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Nrf2 as a therapeutic target for rheumatic diseases
- Source :
- RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia, instname
- Publication Year :
- 2018
-
Abstract
- [EN] Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master regulator of cellular protective processes. Rheumatic diseases are chronic conditions characterized by inflammation, pain, tissue damage and limitations in function. Main examples are rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis and osteoporosis. Their high prevalence constitutes a major health problem with an important social and economic impact. A wide range of evidence indicates that Nrf2 may control different mechanisms involved in the physiopathology of rheumatic conditions. Therefore, the appropriate expression and balance of Nrf2 is necessary for regulation of oxidative stress, inflammation, immune responses, and cartilage and bone metabolism. Numerous studies have demonstrated that Nrf2 deficiency aggravates the disease in experimental models while Nrf2 activation results in immunoregulatory and anti-inflammatory effects. These reports reinforce the increasing interest in the pharmacologic regulation of Nrf2 and its potential applications. Nevertheless, a majority of Nrf2 inducers are electrophilic molecules which may present off-target effects. In recent years, novel strategies have been sought to modulate the Nrf2 pathway which has emerged as a therapeutic target in rheumatic conditions.<br />This work has been funded by grant SAF2017-85806-R (MINECO, FEDER, Spain).
- Subjects :
- 0301 basic medicine
NF-E2-Related Factor 2
Osteoporosis
Inflammation
Disease
Osteoarthritis
medicine.disease_cause
Bioinformatics
digestive system
Biochemistry
environment and public health
Bone remodeling
03 medical and health sciences
Immune system
Systemic lupus erythematosus
Rheumatic Diseases
medicine
Humans
Molecular Targeted Therapy
Rheumatoid arthritis
Pharmacology
business.industry
Nrf2,Rheumatic conditions
respiratory system
medicine.disease
030104 developmental biology
Gene Expression Regulation
Antirheumatic Agents
medicine.symptom
business
Oxidative stress
Subjects
Details
- ISSN :
- 18732968
- Volume :
- 152
- Database :
- OpenAIRE
- Journal :
- Biochemical pharmacology
- Accession number :
- edsair.doi.dedup.....dc802ee69fc061c376d3cc6b1ab19fb4