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Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor

Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor

Authors :
Xiangjun Zeng
Shu-Bin Guo
Jie Du
Hui Yang
Chao-Shu Tang
Li-Ke Zhang
Xiao-Li Dong
Hong-Xia Wang
Hui-Hua Li
Source :
Peptides. 32(10)
Publication Year :
2011

Abstract

Angiotensin II (Ang II) is an important regulator of cardiac function and injury in hypertension. The novel Ang IV peptide/AT4 receptor system has been implicated in several physiological functions and has some effects opposite to those of Ang II. However, little is known about the role of this system in Ang II-induced cardiac injury. Here we studied the effect of Ang IV on Ang II-induced cardiac dysfunction and injury using isolated rat hearts, neonatal cardiomyocytes and cardiac fibroblasts. We found that Ang IV significantly improved Ang II-induced cardiac dysfunction and injury in the isolated heart in response to ischemia/reperfusion (I/R). Moreover, Ang IV inhibited Ang II-induced cardiac cell apoptosis, cardiomyocyte hypertrophy, and proliferation and collagen synthesis of cardiac fibroblasts; these effects were mediated through the AT4 receptor as confirmed by siRNA knockdown. These findings suggest that Ang IV may have a protective effect on Ang II-induced cardiac injury and dysfunction and may be a novel therapeutic target for hypertensive heart disease.

Details

ISSN :
18735169
Volume :
32
Issue :
10
Database :
OpenAIRE
Journal :
Peptides
Accession number :
edsair.doi.dedup.....dc9df38657d1ce6f701083bb3cb9b4a4