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Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor
Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor
- Source :
- Peptides. 32(10)
- Publication Year :
- 2011
-
Abstract
- Angiotensin II (Ang II) is an important regulator of cardiac function and injury in hypertension. The novel Ang IV peptide/AT4 receptor system has been implicated in several physiological functions and has some effects opposite to those of Ang II. However, little is known about the role of this system in Ang II-induced cardiac injury. Here we studied the effect of Ang IV on Ang II-induced cardiac dysfunction and injury using isolated rat hearts, neonatal cardiomyocytes and cardiac fibroblasts. We found that Ang IV significantly improved Ang II-induced cardiac dysfunction and injury in the isolated heart in response to ischemia/reperfusion (I/R). Moreover, Ang IV inhibited Ang II-induced cardiac cell apoptosis, cardiomyocyte hypertrophy, and proliferation and collagen synthesis of cardiac fibroblasts; these effects were mediated through the AT4 receptor as confirmed by siRNA knockdown. These findings suggest that Ang IV may have a protective effect on Ang II-induced cardiac injury and dysfunction and may be a novel therapeutic target for hypertensive heart disease.
- Subjects :
- Cardiac function curve
Male
medicine.medical_specialty
Physiology
Regulator
Ischemia
Biochemistry
Receptor, Angiotensin, Type 1
Muscle hypertrophy
Rats, Sprague-Dawley
Cellular and Molecular Neuroscience
Endocrinology
Internal medicine
medicine
Animals
Myocytes, Cardiac
RNA, Small Interfering
Receptor
Cells, Cultured
Cell Proliferation
Receptors, Angiotensin
business.industry
Angiotensin II
Myocardium
Heart
Hypertrophy
Fibroblasts
medicine.disease
Hypertensive heart disease
Rats
Apoptosis
Reperfusion Injury
cardiovascular system
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 18735169
- Volume :
- 32
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Peptides
- Accession number :
- edsair.doi.dedup.....dc9df38657d1ce6f701083bb3cb9b4a4