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Proteins, Dietary Acid Load, and Calcium and Risk of Postmenopausal Fractures in the E3N French Women Prospective Study
- Source :
- Journal of Bone and Mineral Research, Journal of Bone and Mineral Research, 2008, 23 (12), pp.1915-22. ⟨10.1359/jbmr.080712⟩, Journal of Bone and Mineral Research, American Society for Bone and Mineral Research, 2008, 23 (12), pp.1915-22. ⟨10.1359/jbmr.080712⟩
- Publication Year :
- 2008
- Publisher :
- Wiley, 2008.
-
Abstract
- International audience; Excess dietary proteins and "acid ash" diets have been suspected to increase the risk of osteoporosis, but experimental and epidemiological evidence is mixed. We aimed to determine whether the association between protein intake and the overall acid-base equilibrium of the diet (as renal net acid excretion [RNAE] estimate) and fracture risk vary according to calcium intake. During an average of 8.37 +/- 1.73 yr of follow-up, 2408 women reported a fracture (excluding high-impact trauma) among 36,217 postmenopausal women from the E3N prospective study. We used Cox regression models to study the interaction between calcium and, respectively, proteins and RNAE, from the 1993 dietary questionnaire for fracture risk determination, adjusting for potential confounders. There was no overall association between fracture risk and total protein or RNAE. However, in the lowest quartile of calcium (
- Subjects :
- 030309 nutrition & dietetics
Endocrinology, Diabetes and Metabolism
Osteoporosis
MESH: Dietary Proteins
Fractures, Bone
0302 clinical medicine
Surveys and Questionnaires
Medicine
Orthopedics and Sports Medicine
Prospective Studies
Prospective cohort study
MESH: Aged
0303 health sciences
Hip fracture
education.field_of_study
MESH: Risk
MESH: Middle Aged
Confounding
Middle Aged
Postmenopause
Quartile
Female
Dietary Proteins
France
MESH: Calcium, Dietary
MESH: Postmenopause
MESH: Osteoporosis
Adult
Risk
medicine.medical_specialty
Population
chemistry.chemical_element
030209 endocrinology & metabolism
Calcium
Article
03 medical and health sciences
MESH: Diet
Internal medicine
Humans
education
Aged
MESH: Humans
business.industry
MESH: Questionnaires
MESH: Fractures, Bone
MESH: Adult
medicine.disease
MESH: Prospective Studies
Diet
Calcium, Dietary
MESH: France
Endocrinology
chemistry
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Net acid excretion
business
MESH: Female
Subjects
Details
- ISSN :
- 08840431 and 15234681
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Journal of Bone and Mineral Research
- Accession number :
- edsair.doi.dedup.....dca0eab373b714304daad1026a7b6e31