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Association of Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide with First Ischemic Stroke
- Source :
- Journal of Atherosclerosis and Thrombosis
- Publication Year :
- 2021
- Publisher :
- Japan Atherosclerosis Society, 2021.
-
Abstract
- Aim: We aimed to investigate the relationship of trimethylamine N-oxide (TMAO) concentrations with ischemic stroke in a large-scale case-control study conducted among the hospital-based general population. Methods: We recruited 953 case-control sex- and age-matched pairs, and cases were confined to first acute ischemic stroke in this study. Fasting plasma TMAO was measured using high-performance liquid chromatography–tandem mass spectroscopy. Conditional logistic regression analysis was conducted to calculate odds ratios (OR) for the association of plasma TMAO with ischemic stroke. Results: We found that plasma TMAO concentrations in patients with ischemic stroke were significantly higher than that in the control group (median: 2.85 µmol/L vs. 2.33 µmol/L, P < 0.001). In multivariable conditional logistic regression models, higher plasma TMAO concentrations were associated with increased odds of ischemic stroke [fully adjusted OR for highest vs. lowest TMAO quartile: 1.81; 95% confidence interval (CI): 1.27, 2.59; P for trend < 0.001]. The multivariable-adjusted OR for ischemic stroke per 1 µmol/L increment of plasma TMAO was 1.05 (95% CI: 1.02, 1.08). Additionally, the positive association also persisted in subgroups stratified by age, sex, body mass index, smoking status, alcohol habits, history of diabetes, and history of hypertension. Conclusions: This study suggested a positive association between plasma TMAO and ischemic stroke. Further studies are required to explore the role of plasma TMAO concentrations in predicting stroke risk.
- Subjects :
- Male
China
medicine.medical_specialty
Alcohol Drinking
Case–control study
Population
Trimethylamine N-oxide
030204 cardiovascular system & hematology
Gastroenterology
Body Mass Index
Methylamines
03 medical and health sciences
chemistry.chemical_compound
Sex Factors
0302 clinical medicine
Risk Factors
Tandem Mass Spectrometry
Internal medicine
Diabetes mellitus
Diabetes Mellitus
Internal Medicine
medicine
Humans
Correlation of Data
education
education.field_of_study
Ischemic stroke
business.industry
Smoking
Biochemistry (medical)
Age Factors
Case-control study
Odds ratio
Middle Aged
medicine.disease
Confidence interval
chemistry
Quartile
Case-Control Studies
Hypertension
Original Article
Female
Cardiology and Cardiovascular Medicine
business
Body mass index
030217 neurology & neurosurgery
Chromatography, Liquid
Subjects
Details
- ISSN :
- 18803873 and 13403478
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Atherosclerosis and Thrombosis
- Accession number :
- edsair.doi.dedup.....dca98db0d8d9f8428c62801db62d9e55