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Deregulated profiles of urinary microRNAs may explain podocyte injury and proximal tubule dysfunction in normoalbuminuric patients with type 2 diabetes mellitus
- Source :
- Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 66(4)
- Publication Year :
- 2017
-
Abstract
- MicroRNAs (miRNAs) are short non-coding RNA species that are important post-transcriptional regulators of gene expression. The aim of the study was to establish a potential explanation of podocyte damage and proximal tubule (PT) dysfunction induced by deregulated miRNAs expression in the course of type 2 diabetes mellitus (DM). A total of 68 patients with type 2 DM and 11 healthy subjects were enrolled in a cross-sectional study and assessed concerning urinary albumin:creatinine ratio (UACR), urinary N-acetyl-β-D-glucosamininidase (NAG), urinary kidney injury molecule-1, urinary nephrin, podocalyxin, synaptopodin, estimated glomerular filtration rate (eGFR), urinary miRNA21, miRNA124, and miRNA192. In univariable regression analysis, miRNA21, miRNA124, and miRNA192 correlated with urinary nephrin, synaptopodin, podocalyxin, NAG, KIM-1, UACR, and eGFR. Multivariable regression analysis yielded models in which miRNA192 correlated with synaptopodin, uNAG, and eGFR (R2=0.902; P2=0.881; P2=0.882; P
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Urinary system
Urology
Renal function
030209 endocrinology & metabolism
General Biochemistry, Genetics and Molecular Biology
Podocyte
Nephrin
Kidney Tubules, Proximal
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Medicine
Albuminuria
Humans
Aged
Creatinine
biology
business.industry
Podocytes
Gene Expression Profiling
Type 2 Diabetes Mellitus
General Medicine
Middle Aged
MicroRNAs
030104 developmental biology
medicine.anatomical_structure
chemistry
Podocalyxin
Diabetes Mellitus, Type 2
Multivariate Analysis
biology.protein
Synaptopodin
business
Subjects
Details
- ISSN :
- 17088267
- Volume :
- 66
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of investigative medicine : the official publication of the American Federation for Clinical Research
- Accession number :
- edsair.doi.dedup.....dcacb0539d91a803d7916d28825f0ac1