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Vitamin D pathway related polymorphisms and vitamin D receptor expression in breast cancer

Authors :
Rabeah Al-Temaimi
Noora AlAbdali
Issam M. Francis
Kusum Kapila
Bency John
Source :
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 91(1-2)
Publication Year :
2019

Abstract

Abstract. Vitamin D deficiency is an emerging risk factor for breast cancer suggesting its role in breast cancer pathogenesis. Recent evidence suggests vitamin D receptor (VDR) expression is a prognosis predictor in breast cancer. We set out to determine the status of VDR expression in histologically characterized breast cancers, and whether common genetic variants modify VDR expression in breast cancer. One-hundred and twenty Kuwaiti female breast cancer fixed tissues were assessed for VDR expression to identify the level and location of its expression by immunohistochemistry. VDR variants (rs731236, rs2228570), and vitamin D binding protein ( VDBP) variants (rs4588, rs7041) genotypes were ascertained in breast cancer specimens using Taqman genotyping assays. VDR nuclear expression correlated with low grade tumors (p = 0.01), whereas cytoplasmic expression correlated with lymph node positive tumors (p = 0.03). Absence of VDR expression was a marker for high-grade dedifferentiated tumors (p = 0.01). VDBP rs7041 associated with breast cancer risk (OR 1.92, 95% CI: 1.34 – 2.73; p = 0.0004), and VDR rs2228570 correlated with increased VDR cytoplasmic expression (p

Details

ISSN :
03009831
Volume :
91
Issue :
1-2
Database :
OpenAIRE
Journal :
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
Accession number :
edsair.doi.dedup.....dcb068da4c8bddc2574aa8b19d7421a7