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Vitamin D pathway related polymorphisms and vitamin D receptor expression in breast cancer
- Source :
- International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 91(1-2)
- Publication Year :
- 2019
-
Abstract
- Abstract. Vitamin D deficiency is an emerging risk factor for breast cancer suggesting its role in breast cancer pathogenesis. Recent evidence suggests vitamin D receptor (VDR) expression is a prognosis predictor in breast cancer. We set out to determine the status of VDR expression in histologically characterized breast cancers, and whether common genetic variants modify VDR expression in breast cancer. One-hundred and twenty Kuwaiti female breast cancer fixed tissues were assessed for VDR expression to identify the level and location of its expression by immunohistochemistry. VDR variants (rs731236, rs2228570), and vitamin D binding protein ( VDBP) variants (rs4588, rs7041) genotypes were ascertained in breast cancer specimens using Taqman genotyping assays. VDR nuclear expression correlated with low grade tumors (p = 0.01), whereas cytoplasmic expression correlated with lymph node positive tumors (p = 0.03). Absence of VDR expression was a marker for high-grade dedifferentiated tumors (p = 0.01). VDBP rs7041 associated with breast cancer risk (OR 1.92, 95% CI: 1.34 – 2.73; p = 0.0004), and VDR rs2228570 correlated with increased VDR cytoplasmic expression (p
- Subjects :
- 0301 basic medicine
Genotype
Vitamin D-binding protein
Emerging risk
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Breast Neoplasms
Calcitriol receptor
Polymorphism, Single Nucleotide
vitamin D deficiency
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Breast cancer
medicine
Vitamin D and neurology
Humans
Genetic Predisposition to Disease
Vitamin D
skin and connective tissue diseases
Nutrition and Dietetics
business.industry
General Medicine
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
Case-Control Studies
Cancer research
Receptors, Calcitriol
Female
business
Subjects
Details
- ISSN :
- 03009831
- Volume :
- 91
- Issue :
- 1-2
- Database :
- OpenAIRE
- Journal :
- International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
- Accession number :
- edsair.doi.dedup.....dcb068da4c8bddc2574aa8b19d7421a7