Back to Search
Start Over
Unusual Bicyclo[3.2.1]Octanoid Neolignans from Leaves of Piper crocatum and Their Effect on Pyruvate Dehydrogenase Activity
- Source :
- Plants, Plants, Vol 10, Iss 1855, p 1855 (2021), Volume 10, Issue 9
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Three undescribed bicyclo[3.2.1]octanoid neolignan glucosides, along with a known neolignan, were isolated from the leaves of Piper crocatum Ruiz &amp<br />Pav. Their chemical structures were elucidated using extensive spectroscopic analyses including 1D and 2D NMR experiments and HR-ESI-MS analysis, as well as through comparison with previously reported data. Two compounds were assessed for their inhibitory effect against pyruvate dehydrogenase E1α S300 phosphorylation. The fluorescent image suggested that both compounds (60 µM) revealed a stronger inhibition effect than the positive control (dichloroacetate, DCA 5 mM), with IC50 values of 99.82 µM and 80.25 µM, respectively.
- Subjects :
- Ecology
biology
Bicyclic molecule
Chemistry
Stereochemistry
Botany
neolignan
Plant Science
Pyruvate dehydrogenase activity
Piperaceae
Pyruvate dehydrogenase complex
biology.organism_classification
antineoplastic cell agents
Fluorescence
Article
QK1-989
Phosphorylation
Piper crocatum Ruiz & Pav
Two-dimensional nuclear magnetic resonance spectroscopy
Ecology, Evolution, Behavior and Systematics
Piper crocatum
Subjects
Details
- Language :
- English
- ISSN :
- 22237747
- Volume :
- 10
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Plants
- Accession number :
- edsair.doi.dedup.....dcb9baf1939f4b7986e64554f4b7c6ed