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Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location
- Source :
- Cardiovascular Research, Cardiovascular Research, Oxford University Press (OUP), 2015, 108 (1), pp.62-73. ⟨10.1093/cvr/cvv208⟩, Cardiovascular Research, 2015, 108 (1), pp.62-73. ⟨10.1093/cvr/cvv208⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- International audience; Aims Human epicardial adipose tissue (EAT) is a visceral and perivascular fat that has been shown to act locally on myocardium, atria, and coronary arteries. Its abundance has been linked to coronary artery disease (CAD) and atrial fibrillation. However, its physiological function remains highly debated. The aim of this study was to determine a specific EAT transcriptomic signature, depending on its anatomical peri-atrial (PA), peri-ventricular (PV), or peri-coronary location. Methods and results Samples of EAT and thoracic subcutaneous fat, obtained from 41 patients paired for cardiovascular risk factors, CAD, and atrial fibrillation were analysed using a pangenomic approach. We found 2728 significantly up-regulated genes in the EAT vs. subcutaneous fat with 400 genes being common between PA, PV, and peri-coronary EAT. These common genes were related to extracellular matrix remodelling, inflammation, infection, and thrombosis pathways. Omentin (ITLN1) was the most up-regulated gene and secreted adipokine in EAT (fold-change >12, P
- Subjects :
- Male
medicine.medical_specialty
Physiology
Microarrays
[SDV]Life Sciences [q-bio]
Adipose tissue
Adipokine
Inflammation
Biology
Ectopic fat
Transcriptome
Extracellular matrix
Coronary artery disease
Physiology (medical)
Internal medicine
Epicardial adipose tissue
medicine
Humans
Aged
Aged, 80 and over
Middle Aged
Beige fat
medicine.disease
Phenotype
[SDV] Life Sciences [q-bio]
Coronary arteries
Endocrinology
medicine.anatomical_structure
Adipose Tissue
Female
medicine.symptom
Epicardial fat
Cardiology and Cardiovascular Medicine
Pericardium
Subjects
Details
- Language :
- English
- ISSN :
- 00086363
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Research, Cardiovascular Research, Oxford University Press (OUP), 2015, 108 (1), pp.62-73. ⟨10.1093/cvr/cvv208⟩, Cardiovascular Research, 2015, 108 (1), pp.62-73. ⟨10.1093/cvr/cvv208⟩
- Accession number :
- edsair.doi.dedup.....dccccf7b856458ac9cbd2fd4315420aa