Back to Search
Start Over
Evaluation of adverse reactions to contrast media in the hospital
- Source :
- The British Journal of Radiology. 86:20130418
- Publication Year :
- 2013
- Publisher :
- British Institute of Radiology, 2013.
-
Abstract
- To determine and analyse the characteristics of contrast media adverse reactions (CM-ARs) reported in a hospital.A retrospective review of CM-ARs from the electronic spontaneous adverse drug reaction (ADR) report system between January 2011 and August 2012 was conducted. CM-ARs were evaluated in terms of causality, severity, preventability and affected organs. Also, agreement and correlation among the tools used to evaluate CM-ARs were analysed.The overall reaction rate was 1.5% (n = 286). In total, 269 CM-ARs were identified. For ADR causality, 96.7% (n = 260) and 98.5% (n = 265) were evaluated as "probable" ADR using the Naranjo probability scale and the World Health Organization-Uppsala Monitoring Centre causality categories, whereas 98.1% (n = 264) were evaluated as "certain" with Korean algorithm v. II. Of these, 91.4% (n = 246) were mild in severity and 96.7% (n = 260) were unpreventable. Most patients (n = 233, 86.7%) could be managed with observation and/or simple treatment. The most frequent reaction (n = 383, 79.5%) was dermatological. Spearman's correlation coefficient was 0.667 (p 0.01), and the agreement was 98.1% between the Naranjo scale and the World Health Organization-Uppsala Monitoring Centre categories. No relationship was seen between CM-AR severity and gender or between in- and outpatients.In our study, most CM-ARs were mild and managed with simple treatment. However, as the number of patients undergoing CT procedures continues to increase, it is essential to identify and observe patients at risk for CM-ARs to prevent severe ADRs.Continuous careful review of reporting and treatment protocols of CM-ARs is needed to prevent morbidity and mortality.
- Subjects :
- Adult
Male
Pediatrics
medicine.medical_specialty
Adolescent
Contrast Media
Severity of Illness Index
Skin Diseases
World health
Young Adult
Republic of Korea
Severity of illness
medicine
Adverse Drug Reaction Reporting Systems
Humans
Radiology, Nuclear Medicine and imaging
Young adult
Child
Aged
Retrospective Studies
Aged, 80 and over
Retrospective review
Full Paper
business.industry
Retrospective cohort study
General Medicine
Middle Aged
medicine.disease
Hospitals
Female
business
Adverse drug reaction
Subjects
Details
- ISSN :
- 1748880X and 00071285
- Volume :
- 86
- Database :
- OpenAIRE
- Journal :
- The British Journal of Radiology
- Accession number :
- edsair.doi.dedup.....dcdce3fd1a6ca777adaeafd465afb628