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A new perspective on the pathogenesis of chronic renal disease in captive cheetahs (Acinonyx jubatus)
- Source :
- PLoS ONE, PLoS ONE, Vol 13, Iss 3, p e0194114 (2018)
- Publication Year :
- 2018
- Publisher :
- Public Library of Science (PLoS), 2018.
-
Abstract
- The sustainability of captive cheetah populations is limited by high mortality due to chronic renal disease. This necropsy study, conducted on 243 captive cheetahs from one institution, investigated the relationships between focal palatine erosions, gastritis, enterocolitis, glomerulosclerosis, chronic renal infarcts, renal cortical and medullary fibrosis, and renal medullary amyloidosis at death. Associations between the individual renal lesions and death due to chronic renal disease and comparisons of lesion prevalence between captive bred and wild born and between normal and king coated cheetahs were also assessed. All lesions were significantly positively correlated with age at death. Renal medullary fibrosis was the only lesion associated with the likelihood of death being due to chronic renal disease, and cheetahs with this lesion were younger, on average, than cheetahs with other renal lesions. Alimentary tract lesions were not associated with amyloidosis. All lesions, except for palatine erosions, were more common in wild born than in captive bred cheetahs; the former were older at death than the latter. Having a king coat had no clear effect on disease prevalence. These results suggest that age and renal medullary fibrosis are the primary factors influencing the pathogenesis of chronic renal disease in captive cheetahs. Apart from amyloidosis, these findings are analogous to those described in chronic renal disease in domestic cats, which is postulated to result primarily from repetitive hypoxic injury of renal tubules, mediated by age and stress. Cheetahs may be particularly susceptible to acute renal tubular injury due to their propensity for stress and their extended life span in captivity, as well as their adaptation for fecundity (rather than longevity) and adrenaline-mediated high speed prey chases. The presence of chronic renal disease in subadult cheetahs suggests that prevention, identification and mitigation of stress are critical to the successful prevention of chronic renal disease in captive cheetahs.
- Subjects :
- Male
0301 basic medicine
lcsh:Medicine
Physiology
Pathogenesis
Pathology and Laboratory Medicine
Kidney
urologic and male genital diseases
0403 veterinary science
Mathematical and Statistical Techniques
Fibrosis
Medicine and Health Sciences
Acinonyx jubatus
lcsh:Science
Mammals
Enterocolitis
Multidisciplinary
biology
Amyloidosis
Eukaryota
04 agricultural and veterinary sciences
medicine.anatomical_structure
Nephrology
Gastritis
Vertebrates
Physical Sciences
Female
Disease Susceptibility
medicine.symptom
Statistics (Mathematics)
Research Article
040301 veterinary sciences
Longevity
Gastroenterology and Hepatology
Research and Analysis Methods
Lesion
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Stress, Physiological
biology.animal
Acinonyx
Renal Diseases
medicine
Animals
Statistical Methods
Renal Insufficiency, Chronic
Cheetahs
business.industry
lcsh:R
Organisms
Biology and Life Sciences
medicine.disease
biology.organism_classification
030104 developmental biology
Amniotes
Cats
lcsh:Q
Animals, Zoo
business
Mathematics
Developmental Biology
Generalized Linear Model
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....dce56515bfa94ed5843a031c3d31b0bd