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Targeting acetate metabolism: Achilles’ nightmare
- Source :
- Br J Cancer
- Publication Year :
- 2021
- Publisher :
- Nature Publishing Group UK, 2021.
-
Abstract
- Recent advances in our understanding of tumour heterogeneity alongside studies investigating altered metabolism within transformed tissue have identified metabolic pathways critical to cancer cell survival. Leveraging this information presents a promising new avenue for the generation of cancer-specific therapeutics and improved patient outcomes.
- Subjects :
- Cancer Research
Tumour heterogeneity
Acetate-CoA Ligase
Antineoplastic Agents
Acetates
03 medical and health sciences
Mice
0302 clinical medicine
Neoplasms
medicine
Animals
Humans
Molecular Targeted Therapy
Enzyme Inhibitors
business.industry
Comment
Acetate metabolism
Nightmare
Metabolic pathway
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Cancer cell
Cancer research
medicine.symptom
Altered metabolism
business
Metabolic Networks and Pathways
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Br J Cancer
- Accession number :
- edsair.doi.dedup.....dceacc681062017aea5e8d69b916b60f