Back to Search
Start Over
Decrypting the Origin and Pathogenesis in Pregnant Ewes of a New Ovine Pestivirus Closely Related to Classical Swine Fever Virus
- Source :
- Viruses, Vol 12, Iss 775, p 775 (2020), Dipòsit Digital de Documents de la UAB, Universitat Autònoma de Barcelona, IRTA Pubpro. Open Digital Archive, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Viruses, Volume 12, Issue 7
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- This study shows the origin and the pathogenic role of a novel ovine pestivirus (OVPV) isolated in 2017 in Italy, as a pathogenic agent causing severe abortions after infection in pregnant ewes and high capacity for virus trans-placental transmission as well as the birth of lambs suffering OVPV-persistent infection. The OVPV infection induced early antibody response detected by the specific ELISA against classical swine fever virus (CSFV), another important virus affecting swine. The neutralizing antibody response were similar against CSFV strains from genotype 2 and the OVPV. These viruses showed high identity in the B/C domain of the E2-glycoprotein. Close molecular diagnostics cross-reactivity between CSFV and OVPV was found and a new OVPV molecular assay was developed. The phylodynamic analysis showed that CSFV seems to have emerged as the result of an inter-species jump of Tunisian sheep virus (TSV) from sheep to pigs. The OVPV and the CSFV share the TSV as a common ancestor, emerging around 300 years ago. This suggests that the differentiation of TSV into two dangerous new viruses for animal health (CSFV and OVPV) was likely favored by human intervention for the close housing of multiple species for intensive livestock production. info:eu-repo/semantics/publishedVersion
- Subjects :
- 0301 basic medicine
OVPV
cross-reactivity
lcsh:QR1-502
medicine.disease_cause
Cross-reactivity
lcsh:Microbiology
0403 veterinary science
Pathogenesis
Pregnancy
phylodynamic
Genotype
Neutralizing antibody
Phylogeny
2. Zero hunger
biology
Transmission (medicine)
04 agricultural and veterinary sciences
Abortion, Veterinary
3. Good health
Infectious Diseases
Italy
Classical Swine Fever Virus
RNA, Viral
CSFV
Female
Phylodynamic
Evolution
040301 veterinary sciences
Sheep Diseases
Enzyme-Linked Immunosorbent Assay
Congenital persistent infection
Cross Reactions
Real-Time Polymerase Chain Reaction
congenital persistent infection
Article
Virus
03 medical and health sciences
Virology
evolution
medicine
Animals
pestivirus
Sheep
Pestivirus
Pestivirus Infections
Trans-placental transmission
biology.organism_classification
Antibodies, Neutralizing
trans-placental transmission
030104 developmental biology
Classical swine fever
Antibody Formation
biology.protein
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 12
- Issue :
- 775
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....dd19d7911387bd90ad963d36e15b9632